Mouse anti-Human Complement Component 1 Monoclonal Antibody | anti-C1QBP antibody
Mouse Anti Human Complement Component 1
Gene Names
CR1; KN; C3BR; C4BR; CD35
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Purified from mouse ascitic fluids by protein-A affinity chromatography
Synonyms
Complement Component 1; Monoclonal Antibody; Mouse Anti Human Complement Component 1; C1QBP Antibody; Mouse Anti Human; p32; HABP1; gC1Qr; GC1QBP; SF2p32; gC1Q-R; Complement component 1 Q subcomponent-binding protein mitochondrial; Glycoprotein gC1qBP; C1qBP; GC1q-R protein; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33; C1QBP; anti-C1QBP antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone Number
PAT1G7AT
Purity/Purification
Purified from mouse ascitic fluids by protein-A affinity chromatography
Form/Format
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
Sterile filtered colorless solution.
Sterile filtered colorless solution.
Sequence Length
2489
Applicable Applications for anti-C1QBP antibody
ELISA (EIA), Western Blot (WB)
Application Notes
C1QBP antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity.
Ig Subclass
Mouse IgG1 heavy chain and k light chain.
Immunogen
Anti-human C1QBP mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human C1QBP protein 74-282 amino acids purified from E Coli.
Preparation and Storage
Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
Stability: 12 months at -20 degree C. 1 month at 4 degree C.
Stability: 12 months at -20 degree C. 1 month at 4 degree C.
Related Product Information for anti-C1QBP antibody
C1QBP binds to the globular "heads" of c1q thus inhibiting c1 activation. C1QBP interacts with a wide range of ligands and is implicated in cell signaling. C1QBP associates with C1r and C1s in order to yield the first component of the serum complement system. C1QBP protein has been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.C1QBP is a new marker of tumor cells and tumor-associated macrophages/myeloid cells in hypoxic/metabolically deprived areas of tumors.Mitochondrial C1QBP is a critical mediator of p14ARF-induced apoptosis. C1QBP functions as a chemotactic factor for immature dendritic cells, and migration is mediated through ligation of both C1QBP and cC1qR/CR.C1QBP overexpression successfully blocks mRNA accumulation from the adenovirus major late transcription unit (MLTU) and stimulates RNA polymerase II carboxy-terminal domain phosphorylation in virus-infected cells.C1QBP binds with Hepacivirus core protein on CD8+ and CD4+ positive t-cells and inactivates lck and akt.
Product Categories/Family for anti-C1QBP antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
223,663 Da
NCBI Official Full Name
complement receptor type 1 isoform S
NCBI Official Synonym Full Names
complement component 3b/4b receptor 1 (Knops blood group)
NCBI Official Symbol
CR1
NCBI Official Synonym Symbols
KN; C3BR; C4BR; CD35
NCBI Protein Information
complement receptor type 1
UniProt Protein Name
Complement receptor type 1
Protein Family
UniProt Gene Name
CR1
UniProt Synonym Gene Names
C3BR
UniProt Entry Name
CR1_HUMAN
Uniprot Description
CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: complement component C3b binding; complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity
Biological Process: negative regulation of complement activation, alternative pathway; negative regulation of complement activation, classical pathway; regulation of complement activation
Disease: Knops Blood Group System; Malaria, Susceptibility To
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Product Notes
The C1QBP cr1 (Catalog #AAA140509) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti Human Complement Component 1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Complement Component 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). C1QBP antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Researchers should empirically determine the suitability of the C1QBP cr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Complement Component 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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