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Mouse anti-Human Complement C5a des-Arg Monoclonal Antibody | anti-C5AR2 antibody

Complement C5a des-Arg (Neo-Epitope)

Gene Names
C5AR2; C5L2; GPF77; GPR77
Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry, Neutralization Assay
Purity
Affinity Purified
Purified by Protein G affinity chromatography.
Synonyms
Complement C5a des-Arg; Monoclonal Antibody; Complement C5a des-Arg (Neo-Epitope); Anti -Complement C5a des-Arg (Neo-Epitope); anti-C5AR2 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
6A535
Specificity
Recognizes a neo-epitope on human Complement C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.1% BSA.
Applicable Applications for anti-C5AR2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Neutralization
Immunogen
Human C5a (aa65-73, ISHKDMQLG)
Positive Control
Human granulocytes
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Related Product Information for anti-C5AR2 antibody
C5 is involved in the activation of the lytic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided into the activation pathways and lytic pathway. The activation pathways lead, via C3, to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha IL-1beta, IL-6 and IL-8.
Product Categories/Family for anti-C5AR2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
36,080 Da
NCBI Official Full Name
C5a anaphylatoxin chemotactic receptor 2
NCBI Official Synonym Full Names
complement component 5a receptor 2
NCBI Official Symbol
C5AR2
NCBI Official Synonym Symbols
C5L2; GPF77; GPR77
NCBI Protein Information
C5a anaphylatoxin chemotactic receptor 2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; C5a anaphylatoxin chemotactic receptor C5L2
UniProt Protein Name
C5a anaphylatoxin chemotactic receptor 2
UniProt Gene Name
C5AR2
UniProt Synonym Gene Names
C5L2; GPR77
UniProt Entry Name
C5AR2_HUMAN

NCBI Description

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Description

C5AR2: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: apical part of cell; integral to membrane; basal plasma membrane; plasma membrane

Molecular Function: protein binding; C5a anaphylatoxin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of tumor necrosis factor production; chemotaxis; inflammatory response; positive regulation of epithelial cell proliferation

Research Articles on C5AR2

Similar Products

Product Notes

The C5AR2 c5ar2 (Catalog #AAA601718) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Complement C5a des-Arg (Neo-Epitope) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Complement C5a des-Arg can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Neutralization. Researchers should empirically determine the suitability of the C5AR2 c5ar2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Complement C5a des-Arg, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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