Immunohistochemistry (IHC)
(Anti-Complement C1s antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Mouse anti-Human Complement C1s Monoclonal Antibody | anti-C1S antibody
Anti-Complement C1s Antibody (clone 2D11) IHC-plus
IHC-P (10 ug/ml)
WB (1:2000)
Immunohistochemistry (IHC)
(Anti-Complement C1s antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Immunohistochemistry (IHC)
(Anti-Complement C1s antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Western Blot (WB)
(HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY C1S (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-C1S.)
Western Blot (WB)
(HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY C1S (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-C1S.)
Flow Cytometry (FC/FACS)
(Flow cytometry of HeLa cells, using anti-C1S antibody (Red), compared to a nonspecific negative control antibody (Blue).)
Flow Cytometry (FC/FACS)
(Flow cytometry of HeLa cells, using anti-C1S antibody (Red), compared to a nonspecific negative control antibody (Blue).)
Flow Cytometry (FC/FACS)
(Flow cytometry of Jurkat cells, using anti-C1S antibody (Red), compared to a nonspecific negative control antibody (Blue).)
Flow Cytometry (FC/FACS)
(Flow cytometry of Jurkat cells, using anti-C1S antibody (Red), compared to a nonspecific negative control antibody (Blue).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
Uniprot Description
C1S: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Defects in C1S are the cause of complement component C1s deficiency (C1SD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.42; Protease
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: extracellular region
Molecular Function: calcium ion binding; identical protein binding; protein binding; serine-type endopeptidase activity
Biological Process: complement activation; complement activation, classical pathway; innate immune response; proteolysis
Disease: Complement Component C1s Deficiency
Research Articles on C1S
Similar Products
Product Notes
The C1S c1s (Catalog #AAA249359) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Complement C1s Antibody (clone 2D11) IHC-plus reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Complement C1s can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS). Flow Cytometry (1:100) IHC-P (10 ug/ml) WB (1:2000). Researchers should empirically determine the suitability of the C1S c1s for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Complement C1s, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
