Related Product Information for anti-COL25A1 antibody
Collagen XXV a1 (COL25A1), also known as CLAC-P and AMY, is an 80kD member of the transmembrane (TM) collagen family. It is type II TM hydroxylated glycoprotein that is expressed by neurons. Proteolytic cleavage generates 70kD monomers that either dimerizIgG2Be or trimerize, and bind to fibrillar amyloid b-peptide. Human COL25A1 is 654aa in length. It has a 600aa extracellular domain (aa55-654) that contains seven collagen-like regions and is cleaved by furin between Arg112 and Glu113. Multiple splice forms may exist. One shows a 5aa substitution for (aa441-654), while a second shows a 2aa substitution for (aa616-654). Three other isoforms show splicing over aa165-245 accompanied by complex splicing at the C-terminus. Over (aa189-654), human COL25A1 is 95% aa identical to mouse COL25A1.
Product Categories/Family for anti-COL25A1 antibody
NCBI Description
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
COL25A1: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: extracellular space; collagen; integral to plasma membrane; endoplasmic reticulum lumen; extracellular region; integral to membrane; plasma membrane
Molecular Function: heparin binding; beta-amyloid binding
Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis
Disease: Fibrosis Of Extraocular Muscles, Congenital, 5
Product Notes
The COL25A1 col25a1 (Catalog #
AAA6004272) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Collagen Type XXV, alpha 1 (COL25A1, CLAC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Collagen Type XXV, alpha 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Suitable for use in ELISA and Immunohistochemistry. Dilution: Direct ELISA: 0.5-1ug/ml Immunohistochemistry (paraffin): 25ug/ml Optimal dilutionss to be determined by the researcher. Researchers should empirically determine the suitability of the COL25A1 col25a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"Collagen Type XXV, alpha 1, Monoclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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