Mouse CLOSTRIDIUM DIFFICILE TOXIN B Monoclonal Antibody | anti-toxB antibody

MOUSE ANTI CLOSTRIDIUM DIFFICILE TOXIN B

Cat. Num. AAA219474

• Applications: ELISA
• Synonyms: CLOSTRIDIUM DIFFICILE TOXIN B; Monoclonal Antibody; MOUSE ANTI CLOSTRIDIUM DIFFICILE TOXIN B; anti-toxB antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 5156
• Specificity: This item is specific for Clostridium difficile toxin B. No reaction is observed with toxin A. Clostridium difficile is a gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density and the administration of antibiotics. ; ; Toxin B (TcdB) is a large exotoxin. Its role in disease is less well understood than that of toxin A, though it seems clear that TcdB contributes to disease. Both toxins modifies the Ras superfamily of small GTPases via glycosylation, inactivating them and leading to the disruption of vital signaling pathways in the cell.
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 0.1mg/ml (varies by lot)
• Sequence Length: 2366

• Applicable Applications for anti-toxB antibody: ELISA (EIA)
• Application Notes: ELISA: Minimum Dilution: 1/20; Maximum Dilution: 1/200
• Perservative Stabilisers: 0.1% Sodium Azide (NaN3) ; Preparation
• Buffer Solution: Phosphate buffered saline
• Target Species: Bacterial
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-toxB antibody

MBS219474 is specific for Clostridium difficile toxin B. No reaction is observed with toxin A. Clostridium difficile isa gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density and the administration of antibiotics. Toxin B (TcdB) is a large exotoxin. Its role in disease is less well understood than that of toxin A, though it seems clear that TcdB contributes to disease. Both toxins modifies the Ras superfamily of small GTPases via glycosylation, inactivating them and leading to the disruption of vital signaling pathways in the cell.

NCBI and Uniprot Product Information

• NCBI GI #: 136015
• UniProt Accession #: P18177
• Molecular Weight: 269,712 Da
• NCBI Official Full Name: Toxin B
• UniProt Protein Name: Toxin B
• Protein Family: Toxin
• UniProt Gene Name: toxB
• UniProt Synonym Gene Names: tcdB
• UniProt Entry Name: TOXB_PEPDI

Uniprot Description

Cytotoxin.