Mouse CKMM Monoclonal Antibody | anti-CKMM antibody

CKMM antibody

Cat. Num. AAA531102

• Gene Names: CKM; CKMM; M-CK
• Reactivity: To be determined by end-user
• Applications: User optimized
• Purity: > 90% pure
• Synonyms: CKMM; Monoclonal Antibody; CKMM antibody; Monoclonal CKMM; Anti-CKMM; Creatine Kinase-MM Isoenzyme; CK-MM; anti-CKMM antibody

• Host: Mouse
• Reactivity: To be determined by end-user
• Clonality: Monoclonal
• Isotype: IgG1 kappa
• Clone Number: M52213
• Purity/Purification: > 90% pure
• Form/Format: Protein A purified and supplied in 10mM PBS, pH 7.2 with 0.05% NaN3.
• Concentration: Typically 3-5 mg/ml (varies by lot)
• Sequence Length: 381

• Applicable Applications for anti-CKMM antibody: User optimized
• Biological Significance: Creatine kinase (CK), is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). In the cells, the "cytosolic" CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). There are, therefore, three different isoenzymes: CK-MM, C kbB and CK-MB.
• Immunogen: CKMM antibody was raised in mouse using CK-MM purified from human smooth muscle as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-CKMM antibody

Mouse monoclonal CKMM antibody

Product Categories/Family for anti-CKMM antibody

Cardiac Markers

NCBI and Uniprot Product Information

• NCBI GI #: 21536288
• NCBI GeneID: 1158
• NCBI Accession #: NP_001815.2
• NCBI GenBank Nucleotide #: NM_001824.4
• Molecular Weight: 43,101 Da
• NCBI Official Full Name: creatine kinase M-type
• NCBI Official Synonym Full Names: creatine kinase, muscle
• NCBI Official Symbol: CKM
• NCBI Official Synonym Symbols: CKMM; M-CK
• NCBI Protein Information: creatine kinase M-type
• UniProt Protein Name: Creatine kinase M-type
• UniProt Gene Name: CKM
• UniProt Synonym Gene Names: CKMM
• UniProt Entry Name: KCRM_HUMAN

NCBI Description

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

Uniprot Description

CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.

Protein type: Kinase, other; Amino Acid Metabolism - arginine and proline; EC 2.7.3.2

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol

Molecular Function: creatine kinase activity; ATP binding

Biological Process: phosphocreatine biosynthetic process; phosphorylation; creatine metabolic process