Mouse anti-Human CIITA Monoclonal Antibody | anti-CIITA antibody

CIITA (Class II Trans Activator, C2TA, CIITA IV, MHC2TA, MHC Class II Transactivator)

Cat. Num. AAA604860

• Gene Names: CIITA; C2TA; NLRA; MHC2TA; CIITAIV
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: CIITA; Monoclonal Antibody; CIITA (Class II Trans Activator; C2TA; CIITA IV; MHC2TA; MHC Class II Transactivator); Anti -CIITA (Class II Trans Activator; anti-CIITA antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 9F612
• Specificity: Recognizes human CIITA.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.

• Applicable Applications for anti-CIITA antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunoprecipitation.
• Immunogen: Recombinant human CIITA fusion protein
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-CIITA antibody

CIITA is a non-DNA binding coactivator considered as the master regulator of basal and induced MHC class II specific gene expression. CIITA ensures a tight transcriptional control of these antigen-presenting genes to meet with local requirements for an adequate immune response.

Product Categories/Family for anti-CIITA antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 51558027
• NCBI GeneID: 4261
• UniProt Accession #: P33076; D3DUG0
• Molecular Weight: 123,514 Da
• NCBI Official Full Name: CIITA IV
• NCBI Official Synonym Full Names: class II, major histocompatibility complex, transactivator
• NCBI Official Symbol: CIITA
• NCBI Official Synonym Symbols: C2TA; NLRA; MHC2TA; CIITAIV
• NCBI Protein Information: MHC class II transactivator; NLR family, acid domain containing; MHC class II transactivator type III; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
• UniProt Protein Name: MHC class II transactivator
• Protein Family: MHC class II transactivator
• UniProt Gene Name: CIITA
• UniProt Synonym Gene Names: MHC2TA; CIITA
• UniProt Entry Name: C2TA_HUMAN

NCBI Description

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]

Uniprot Description

CIITA: a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production.

Protein type: Transcription, coactivator/corepressor; DNA-binding; EC 2.7.11.1

Chromosomal Location of Human Ortholog: 16p13

Cellular Component: nucleoplasm; PML body

Molecular Function: protein C-terminus binding; protein binding; DNA binding; GTP binding; transcription activator binding; transcription coactivator activity; transferase activity, transferring acyl groups; protein complex binding; kinase activity; ATP binding

Biological Process: response to antibiotic; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; negative regulation of collagen biosynthetic process; positive regulation of MHC class II biosynthetic process; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of MHC class I biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphorylation

Disease: Rheumatoid Arthritis; Bare Lymphocyte Syndrome, Type Ii