Western Blot (WB)
(Western blot detection of CHRDL1 in human eye and Hela cell lysates using CHRDL1 mouse mAb (1:1000 diluted).Predicted band size: 57kDa.Observed band size: 52kDa.)
Mouse anti-Human CHRDL1 Monoclonal Antibody | anti-CHRDL1 antibody
CHRDL1 Antibody
ICC ~~ 1:300
Western Blot (WB)
(Western blot detection of CHRDL1 in human eye and Hela cell lysates using CHRDL1 mouse mAb (1:1000 diluted).Predicted band size: 57kDa.Observed band size: 52kDa.)
Western Blot (WB)
(Western blot detection of CHRDL1 in human eye and Hela cell lysates using CHRDL1 mouse mAb (1:1000 diluted).Predicted band size: 57kDa.Observed band size: 52kDa.)
Immunocytochemistry (ICC)
(Immunocytochemistry stain of Hela using CHRDL1 mouse mAb (1:300).)
Immunocytochemistry (ICC)
(Immunocytochemistry stain of Hela using CHRDL1 mouse mAb (1:300).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Uniprot Description
CHRDL1: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. Defects in CHRDL1 are the cause of megalocornea type 1, X-linked (MGC1). MGC1 is an eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: Xq23
Cellular Component: extracellular region
Biological Process: BMP signaling pathway; nervous system development; ossification; eye development; compound eye development; cell differentiation; negative regulation of BMP signaling pathway
Disease: Megalocornea
Research Articles on CHRDL1
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Product Notes
The CHRDL1 chrdl1 (Catalog #AAA9215443) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CHRDL1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CHRDL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC). WB ~~ 1:1000 ICC ~~ 1:300. Researchers should empirically determine the suitability of the CHRDL1 chrdl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CHRDL1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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