Mouse anti-Human CELSR3 Monoclonal Antibody | anti-CELSR3 antibody

CELSR3 (Cadherin EGF LAG Seven-pass G-type Receptor 3, Flamingo Homolog, hFmi1, Multiple epidermal growth factor-like domains 2, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2)

Cat. Num. AAA606120

• Gene Names: CELSR3; FMI1; EGFL1; HFMI1; MEGF2; CDHF11; RESDA1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: CELSR3; Monoclonal Antibody; CELSR3 (Cadherin EGF LAG Seven-pass G-type Receptor 3; Flamingo Homolog; hFmi1; Multiple epidermal growth factor-like domains 2; CDHF11; EGFL1; FMI1; KIAA0812; MEGF2); Anti -CELSR3 (Cadherin EGF LAG Seven-pass G-type Receptor 3; anti-CELSR3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 9G337
• Specificity: Recognizes human Epidermal growth factor-like 1.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-CELSR3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.
• Immunogen: Partial recombinant protein of human Epidermal growth factor-like 1 (aa71-180) with a GST tag.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis using GST-tagged partial recombinant CELR3 (aa 71-180) as sample.)

ELISA (EIA)

(In sandwhich ELISA, MBS606120 has a detection limit of 0.03ng/ml for the GST tagged partial recombinant CELR3 protein.)

Related Product Information for anti-CELSR3 antibody

Epidermal growth factor-like 1 belongs to the G-protein coupled receptor 2 family and the LN-TM7 subfamily. The unprocessed precursor has a length of 3312 amino acids and a predicted molecular weight of 358.3kD. It contains nine cadherin domains, eight EGF-like domains, one GPS domains, one laminin EGF-like domains and two laminin G-like domains. It is a transmembrane protein and is thought to have an important role in cell to cell signaling during nervous system formation.

Product Categories/Family for anti-CELSR3 antibody

Antibodies; Abs to Cadherin

NCBI and Uniprot Product Information

• NCBI GI #: 145309304
• NCBI GeneID: 1951
• NCBI Accession #: NP_001398.2
• NCBI GenBank Nucleotide #: NM_001407.2
• UniProt Accession #: Q9NYQ7; O75092
• Molecular Weight: 358,185 Da
• NCBI Official Full Name: cadherin EGF LAG seven-pass G-type receptor 3
• NCBI Official Synonym Full Names: cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
• NCBI Official Symbol: CELSR3
• NCBI Official Synonym Symbols: FMI1; EGFL1; HFMI1; MEGF2; CDHF11; RESDA1
• NCBI Protein Information: cadherin EGF LAG seven-pass G-type receptor 3; anchor protein; EGF-like protein 1; OTTHUMP00000164826; flamingo homolog 1; cadherin family member 11; EGF-like-domain, multiple 1; multiple EGF-like domains 2; epidermal growth factor-like 1; multiple EGF-like domains protein 2; epidermal growth factor-like protein 1; multiple epidermal growth factor-like domains protein 2
• UniProt Protein Name: Cadherin EGF LAG seven-pass G-type receptor 3
• Protein Family: Cadherin EGF LAG seven-pass G-type receptor
• UniProt Gene Name: CELSR3
• UniProt Synonym Gene Names: CDHF11; EGFL1; FMI1; KIAA0812; MEGF2
• UniProt Entry Name: CELR3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq]

Uniprot Description

CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; protein binding; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of protein localization; neuron migration; axonal fasciculation; cilium biogenesis; homophilic cell adhesion