Rabbit anti-Human CEACAM1  Monoclonal Antibody | anti-CEACAM1  antibody

Rabbit anti Human CEACAM1  Monoclonal Antibody

Cat. Num. AAA2544089

• Gene Names: CEACAM1; BGP; BGP1; BGPI
• Reactivity: Human
• Applications: ELISA
• Synonyms: CEACAM1 ; Monoclonal Antibody; Rabbit anti Human CEACAM1 Monoclonal Antibody; anti-CEACAM1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 468

• Applicable Applications for anti-CEACAM1 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CEACAM1. The detection limit for Human CEACAM1 is approximately 0.00975 ng/well.
• Immunogen: Recombinant Human CEACAM1 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CEACAM1  antibody

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

NCBI and Uniprot Product Information

• NCBI GI #: 329112547
• NCBI GeneID: 634
• NCBI GenBank Nucleotide #: NM_001205344.1
• Molecular Weight: 39,871 Da
• NCBI Official Full Name: carcinoembryonic antigen-related cell adhesion molecule 1 isoform 6
• NCBI Official Synonym Full Names: carcinoembryonic antigen related cell adhesion molecule 1
• NCBI Official Symbol: CEACAM1
• NCBI Official Synonym Symbols: BGP; BGP1; BGPI
• NCBI Protein Information: carcinoembryonic antigen-related cell adhesion molecule 1
• UniProt Protein Name: Carcinoembryonic antigen-related cell adhesion molecule 1
• UniProt Gene Name: CEACAM1
• UniProt Synonym Gene Names: BGP-1
• UniProt Entry Name: CEAM1_HUMAN

NCBI Description

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

Uniprot Description

CEACAM1: carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: adherens junction; apical plasma membrane; basal plasma membrane; cell junction; cell surface; integral to membrane; intercellular junction; lateral plasma membrane; membrane; plasma membrane; T cell receptor complex

Molecular Function: actin binding; bile acid transmembrane transporter activity; filamin binding; kinase binding; protein binding; protein dimerization activity; protein homodimerization activity; protein phosphatase binding

Biological Process: bile acid and bile salt transport; blood vessel development; cell adhesion; cellular response to insulin stimulus; homophilic cell adhesion; leukocyte migration; negative regulation of cytotoxic T cell degranulation; negative regulation of fatty acid biosynthetic process; negative regulation of granulocyte differentiation; negative regulation of interleukin-1 production; negative regulation of lipid biosynthetic process; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of protein kinase activity; negative regulation of T cell mediated cytotoxicity; negative regulation of T cell receptor signaling pathway; negative regulation of vascular permeability; regulation of cell growth; regulation of cell migration; regulation of endothelial cell differentiation; regulation of epidermal growth factor receptor signaling pathway; regulation of phosphoinositide 3-kinase cascade