Mouse CDKN2 Monoclonal Antibody | anti-CDKN2 antibody
CDKN2 antibody
Applications
Western Blot, Immunohistochemistry, Immunocytochemistry
Synonyms
CDKN2; Monoclonal Antibody; CDKN2 antibody; Monoclonal CDKN2; Anti-CDKN2; CDKNA-2; Multiple tumor suppressor 1; CDKNA 2; CMM2; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; MTS1; ARF; mlM; CDKN2A; INK4; CDK4I; anti-CDKN2 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
IMD-16
Form/Format
Supplied in lyophilized form
Applicable Applications for anti-CDKN2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Formalin, Immunocytochemistry (ICC)
Application Notes
Optimal conditions to be determined by the end user
Biological Significance
CDKN2A is capable of inducing cell cycle arrest in G1 and G2 phases. It also acts as a tumor suppressor. CDKN2A binds to MDM2 andblocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.
Immunogen
CDKN2 antibody was raised in mouse using recombinant human p16 protein as the immunogen
Preparation and Storage
Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C, avoid repeated freeze/thaw cycles.
Related Product Information for anti-CDKN2 antibody
Mouse monoclonal CDKN2A antibody
Product Categories/Family for anti-CDKN2 antibody
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Product Notes
The CDKN2 (Catalog #AAA832405) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CDKN2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Formalin, Immunocytochemistry (ICC). Optimal conditions to be determined by the end user. Researchers should empirically determine the suitability of the CDKN2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDKN2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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