Mouse anti-Human CDH3/P-Cadherin Monoclonal Antibody | anti-CDH3 antibody

Anti-CDH3/P-Cadherin Antibody (clone 2D5)

Cat. Num. AAA2401628

• Gene Names: CDH3; CDHP; HJMD; PCAD
• Reactivity: Human
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: CDH3/P-Cadherin; Monoclonal Antibody; Anti-CDH3/P-Cadherin Antibody (clone 2D5); Mouse Monoclonal (IgG1) to Human CDH3/P-Cadherin; CDH3; Cadherin-3; HJMD; P-cadherin; CDHP; PCAD; Placental cadherin; anti-CDH3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 2D5
• Specificity: Human CDH3/P-Cadherin
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
• Sequence Length: 829

• Applicable Applications for anti-CDH3 antibody: Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IF: 1:100; IHC-P: 10 ug/ml; WB: 1:4000
• Immunogen: Full length human Recombinant protein of human CDH3(NP_001784) produced in HEK293T cell.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunofluorescence (IF)

(Immunofluorescent staining of HeLa cells using anti-CDH3 mouse monoclonal antibody.)

Immunofluorescence (IF)

(Anti-CDH3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CDH3.)

Western Blot (WB)

(HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDH3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDH3.)

Related Product Information for anti-CDH3 antibody

P-Cadherin is a classical cadherin from the cadherin superfamily. the encoded protein is a calcium-dependent cell-cell adhesion glycoproteincomprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in asix-cadherin cluster in a region on the long arm of chromosome 16 thatis involved in loss of heterozygosity events in breast and prostatecancer.

Product Categories/Family for anti-CDH3 antibody

Cadherin

NCBI and Uniprot Product Information

• NCBI GI #: 14589891
• NCBI GeneID: 1001
• NCBI Accession #: NP_001784.2
• NCBI GenBank Nucleotide #: NM_001793.5
• UniProt Accession #: P22223; Q05DI6; B2R6F4
• Molecular Weight: 86,552 Da
• NCBI Official Full Name: cadherin-3 isoform 1 preproprotein
• NCBI Official Synonym Full Names: cadherin 3
• NCBI Official Symbol: CDH3
• NCBI Official Synonym Symbols: CDHP; HJMD; PCAD
• NCBI Protein Information: cadherin-3
• UniProt Protein Name: Cadherin-3
• UniProt Gene Name: CDH3
• UniProt Synonym Gene Names: CDHP; P-cadherin

NCBI Description

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]

Uniprot Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.