Mouse anti-Human CD91a Monoclonal Antibody

CD91a (a2-Macroglobulin Receptor, a2MR)

Cat. Num. AAA602360

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay, Immunofluorescence
• Purity: Affinity Purified; Highly purified from mouse ascites by protein A chromatography.
• Synonyms: CD91a; Monoclonal Antibody; CD91a (a2-Macroglobulin Receptor; a2MR); Anti -CD91a (a2-Macroglobulin Receptor; anti-CD91a antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 4H306
• Specificity: Specific for the a-chain of human CD91 protein. On Western blots, it identifies a band at ~515kD. Reactivity has been confirmed with pure CD91 protein an human liver and placenta homogenates by Western blotting, as well as with frozen human liver, brain, lymph node, duodenum and kidney.1
• Purity/Purification: Affinity Purified; Highly purified from mouse ascites by protein A chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

• Applicable Applications for anti-CD91a antibody: Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunofluorescence, Flow Cytometry, Western Blot, Immunohistochemistry.; Dilution: Immunofluorescence: 10ug/ml; Flow Cytometry: 10ug/ml; Western Blot: 1ug/ml; Immunohistochemistry (frozen): 10ug/ml
• Immunogen: Purified human CD91 alpha chain protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-CD91a antibody

CD91, also known as a2-macroglobulin receptor (a2MR1. Moestrup SK, et al. Cell Tissue Res 269:374-382, 1992. 2. Moestrup SK and Hokland P. Leuk Res 16(3):227-234, 1992. 3. Strickland DK, et al. J Biol Chem 265:17401-17404, 1990.), apolipoprotein E receptor (ApoER) and low density lipoprotein receptor-related protein (LRP), is a large two-chain membrane protein that binds the proteinase-activated form of the plasma membrane protein a2M.1 a2M is a proteinase-inhibitor containing a region that is a substrate for a wide range of proteinases including trypsin, chymotrypsin, plasmin, neutrophil elastase and fibroblast collagenase.1 Binding of a2M:proteinase complexes to a2MR is followed by endocytosis and degradation of the ligand in lysosomes. CD91 consists of two non-covalently associated polypeptides of ~420 to ~85kD, and has been shown to be present in a restricted spectrum of cell types, including neurons and astrocytes in the central nervous system, epithelial cells in the gastrointestinal tract, smooth muscle cells, fibroblasts, Leydig cells in testis, granulose cells in ovary, and dendritic interstitial cells of kidney.1 The high abundance of CD91 in certain cells types of most organs suggest two different mechanisms of CD91 -mediated ligand clearance.1 CD91 is expressed on malignant cells from patients with acute and chronic myelomonocytic leukemia, while no significant expression was found on malignant cells from acute and chronic lymphatic leukemia, lymphomas, plasma cell leukemias or hairy cell leukemia. CD91 was also shown to have a close correlation with CD14 surface expression.

Product Categories/Family for anti-CD91a antibody

Antibodies; Abs to CD Markers