Rabbit anti-Mouse CD83  Monoclonal Antibody | anti-CD83  antibody

Rabbit anti Mouse CD83  Monoclonal Antibody

Cat. Num. AAA2544646

• Gene Names: CD83; BL11; HB15
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: CD83 ; Monoclonal Antibody; Rabbit anti Mouse CD83 Monoclonal Antibody; anti-CD83 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 205

• Applicable Applications for anti-CD83 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse CD83. The detection limit for Mouse CD83 is approximately 0.0012 ng/well.
• Immunogen: Recombinant Mouse CD83 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CD83  antibody

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD83 is considered as a marker of mature dendritic cells as well as an adhesion receptor that binds to resting monocytes and a subset of activated CD8+ T cells. In certain conditions, CD83 tended to dimerize or even multimerize through its aberrant intermolecular disulfide bonds. The injection of CD83-Ig can significantly enhaunce the rate of tumor growth and inhibit the T cell growth.

NCBI and Uniprot Product Information

• NCBI GI #: 4757946
• NCBI GeneID: 9308
• NCBI GenBank Nucleotide #: NM_004233.3
• Molecular Weight: 23,042 Da
• NCBI Official Full Name: CD83 antigen isoform a
• NCBI Official Synonym Full Names: CD83 molecule
• NCBI Official Symbol: CD83
• NCBI Official Synonym Symbols: BL11; HB15
• NCBI Protein Information: CD83 antigen
• UniProt Protein Name: CD83 antigen
• UniProt Gene Name: CD83
• UniProt Synonym Gene Names: hCD83
• UniProt Entry Name: CD83_HUMAN

NCBI Description

The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

CD83: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p23

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: defense response; humoral immune response; regulation of cytokine production; signal transduction