Immunofluorescence (IF)
(Confocal immunofluorescence analysis of BCBL-1 cells using anti-CD80 monoclonal antioby (green), showing membrane localization. Blue)
Mouse anti-Human CD80 Monoclonal Antibody | anti-CD80 antibody
Anti-CD80 Mouse mAb
Gene Names
CD80; B7-1
Reactivity
Human
Applications
Immunohistochemistry, Immunocytochemistry
Synonyms
CD80; Monoclonal Antibody; Anti-CD80 Mouse mAb; CD28LG; LAB7; B7.1; anti-CD80 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2A2
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Sequence Length
296
Applicable Applications for anti-CD80 antibody
Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Immunogen
Purified recombinant fragment of CD80 expressed in E Coli.
Immunofluorescence (IF)
(Confocal immunofluorescence analysis of BCBL-1 cells using anti-CD80 monoclonal antioby (green), showing membrane localization. Blue)
Immunofluorescence (IF)
(Confocal immunofluorescence analysis of BCBL-1 cells using anti-CD80 monoclonal antioby (green), showing membrane localization. Blue)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using anti-CD80 mAb)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using anti-CD80 mAb)
Related Product Information for anti-CD80 antibody
Entrez Summary: The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin; Estrogen stimulates osteoprotegerin production.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
55
NCBI Official Full Name
CD80
NCBI Official Symbol
CD80
NCBI Official Synonym Symbols
B7-1
NCBI Protein Information
T-lymphocyte activation antigen CD80
UniProt Protein Name
CD80
Protein Family
UniProt Gene Name
CD80
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Product Notes
The CD80 cd80 (Catalog #AAA475913) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD80 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD80 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the CD80 cd80 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD80, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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