Testing Data
(Staining of human peripheral blood platelets with Mouse anti Human CD49b (MBS212451))
Mouse CD49b Monoclonal Antibody | anti-CD49b antibody
MOUSE ANTI HUMAN CD49b
Purified IgG - liquid
Tris/EDTA pH9.0 is recommended for this purpose.
(2)This product contains sodium azide, removal by dialysis is recommended prior to use in functional assays.
Dilutions:
Flow Cytometry:30ug/ml
Immunohistology-Frozen: 30ug/ml - 40ug/ml
ELISA: 10ug/ml
Immunoprecipitation: 25ug/ml - 50ug/ml
Shelf Life: 18 months from date of despatch.
Testing Data
(Staining of human peripheral blood platelets with Mouse anti Human CD49b (MBS212451))
Testing Data
(Staining of human peripheral blood platelets with Mouse anti Human CD49b (MBS212451))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Description
ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family.
Protein type: Cell adhesion; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: focal adhesion; cell surface; perinuclear region of cytoplasm; plasma membrane; nerve terminal; nucleus; integrin complex; external side of plasma membrane
Molecular Function: collagen binding; integrin binding; viral receptor activity; protein binding; protein heterodimerization activity; metal ion binding; laminin binding
Biological Process: axon guidance; response to muscle activity; extracellular matrix organization and biogenesis; entry of virus into host cell; positive regulation of positive chemotaxis; positive regulation of cell adhesion; positive regulation of translation; cell-matrix adhesion; positive regulation of smooth muscle cell proliferation; positive regulation of leukocyte migration; positive regulation of collagen binding; positive regulation of collagen biosynthetic process; positive regulation of cell projection organization and biogenesis; mesodermal cell differentiation; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to organic cyclic substance; establishment of protein localization; mammary gland development; positive regulation of smooth muscle contraction; cell adhesion; positive regulation of DNA binding; response to drug; integrin-mediated signaling pathway; substrate-bound cell migration; skin morphogenesis; hypotonic response; cell-substrate adhesion; cellular response to hormone stimulus; detection of mechanical stimulus involved in sensory perception of pain; cell proliferation; organ morphogenesis; response to hypoxia; cell adhesion mediated by integrin; blood coagulation; positive regulation of phagocytosis, engulfment; positive regulation of inflammatory response; response to amine stimulus; positive regulation of transmission of nerve impulse
Disease: Bleeding Disorder, Platelet-type, 9
Research Articles on CD49b
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Product Notes
The CD49b itga2 (Catalog #AAA215438) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MOUSE ANTI HUMAN CD49b reacts with Human; Does not react with:Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD49b can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry, Immunohistology - Frozen,Paraffin (1), ELISA, Immunoprecipitation, Western Blotting, Immunofluorescence,Functional Assays (2). (1) This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Tris/EDTA pH9.0 is recommended for this purpose. (2)This product contains sodium azide, removal by dialysis is recommended prior to use in functional assays. Dilutions: Flow Cytometry:30ug/ml Immunohistology-Frozen: 30ug/ml - 40ug/ml ELISA: 10ug/ml Immunoprecipitation: 25ug/ml - 50ug/ml. Researchers should empirically determine the suitability of the CD49b itga2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD49b, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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