Rat anti-Mouse CD44/Pgp-1 Monoclonal Antibody | anti-CD44/Pgp-1 antibody

Anti-Mouse CD44/Pgp-1-UNLB Antibody

Cat. Num. AAA4151524

• Reactivity: Mouse
• Applications: Flow Cytometry, Functional Assay, Immunoprecipitation
• Purity: Affinity Purified
• Synonyms: CD44/Pgp-1; Monoclonal Antibody; Anti-Mouse CD44/Pgp-1-UNLB Antibody; anti-CD44/Pgp-1 antibody

• Host: Rat
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 kappa
• Specificity: All isoforms of CD44/pgp-1 (Mr 80-95 kDa)
• Purity/Purification: Affinity Purified
• Form/Format: Liquid
• Concentration: 100ug/200ul (varies by lot)
• Sequence Length: 368

• Applicable Applications for anti-CD44/Pgp-1 antibody: Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
• Storage Buffer: PBS, pH 7.4 with 0.05% sodium azide.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at -20 degree C or below.; Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-CD44/Pgp-1 antibody

CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. The KM201 monoclonal antibody reacts with an epitope very close to the hyaluronate binding domain on the CD44 molecule. KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte Cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells.

NCBI and Uniprot Product Information

• NCBI GI #: 291490675
• NCBI GeneID: 281057
• NCBI Accession #: NP_776438.2
• NCBI GenBank Nucleotide #: NM_174013.3
• Molecular Weight: 40,002 Da
• NCBI Official Full Name: CD44 antigen
• NCBI Official Synonym Full Names: CD44 molecule
• NCBI Official Symbol: CD44
• NCBI Protein Information: CD44 antigen
• UniProt Protein Name: CD44 antigen
• UniProt Gene Name: CD44
• UniProt Synonym Gene Names: ECMR-III; PGP-1; PGP-I

Uniprot Description

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function.