Mouse anti-Human CD39 Monoclonal Antibody | anti-CD39 antibody

Anti-Hu CD39 PE

Cat. Num. AAA1801635

• Gene Names: ENTPD1; CD39; SPG64; ATPDase; NTPDase-1
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Synonyms: CD39; Monoclonal Antibody; Anti-Hu CD39 PE; ectonucleoside triphosphate diphosphohydrolase 1; ETDH1; Ecto-ATPase 1; Lymphoid cell activation antigen; Ecto-apyrase; ENTPD1; anti-CD39 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b kappa
• Clone Number: TU66
• Specificity: The mouse monoclonal antibody TU66, also known as Tü66, recognizes an extracellular epitope of CD39, a 78 kDa cell surface enzyme expressed by regulatory T cells, mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets.
• Purity/Purification: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Form/Format: Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
• Sequence Length: 517

• Applicable Applications for anti-CD39 antibody: Flow Cytometry (FC/FACS)
• Application Notes: FC/FACS: QC tested
• Conjugation: PE
• Preparation and Storage: Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.

Flow Cytometry (FC/FACS)

(Flow cytometry analysis (surface staining) of CD39 in human peripheral blood with anti-CD39 (TU66) PE.)

Related Product Information for anti-CD39 antibody

CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), is a cell surface enzyme (with intracellular N- and C-terminus) which hydrolyzes extracellular ATP and ADP to AMP. Inhibition of its enzymatic activity may confer anticancer benefits. The formation of oligomers in the plasma membrane is essential for enzyme activity. It is expressed on Treg cells, and in other cell types, such as mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets. Hydrolysis of ATP and ADP inhibits inflammatory and thrombotic responses. In the nervous system, it regulates purinergic neurotransmission.

NCBI and Uniprot Product Information

• NCBI GI #: 147905700
• NCBI GeneID: 953
• NCBI Accession #: NP_001091645.1
• NCBI GenBank Nucleotide #: NP_001091645.1
• UniProt Accession #: P49961
• NCBI Official Full Name: ectonucleoside triphosphate diphosphohydrolase 1 isoform 2
• NCBI Official Synonym Full Names: ectonucleoside triphosphate diphosphohydrolase 1
• NCBI Official Symbol: ENTPD1
• NCBI Official Synonym Symbols: CD39; SPG64; ATPDase; NTPDase-1
• NCBI Protein Information: ectonucleoside triphosphate diphosphohydrolase 1
• UniProt Protein Name: Ectonucleoside triphosphate diphosphohydrolase 1
• UniProt Gene Name: ENTPD1
• UniProt Synonym Gene Names: CD39; NTPDase 1; Ecto-ATPDase 1
• UniProt Entry Name: ENTP1_HUMAN

NCBI Description

The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Description

ENTPD1: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. Belongs to the GDA1/CD39 NTPase family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Nucleotide Metabolism - purine; EC 3.6.1.5; Extracellular matrix; Nucleotide Metabolism - pyrimidine; Membrane protein, multi-pass; Hydrolase

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: membrane; integral to plasma membrane; plasma membrane; basal lamina

Molecular Function: protein binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; ATP binding

Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; purine ribonucleoside diphosphate catabolic process; cell adhesion; blood coagulation

Disease: Spastic Paraplegia 64, Autosomal Recessive