Testing Data
(Staining of mouse peripheral blood platelets with RAT ANTI MOUSE CD36:Low Endotoxin(MBS605199).)
Rat anti-Mouse CD36, Low Endotoxin Monoclonal Antibody | anti-CD36 antibody
CD36, Low Endotoxin (gpIIIb, gpIV, Thrombospondin Receptor)
Purified by Protein G affinity chromatography. Endotoxin: 0.01EU/ug.
Purified by Protein G affinity chromatography. Endotoxin: 0.01EU/ug.
Dilution: Flow Cytometry: 10ul labels 1x10e6 cells in 100ul.
Testing Data
(Staining of mouse peripheral blood platelets with RAT ANTI MOUSE CD36:Low Endotoxin(MBS605199).)
Testing Data
(Staining of mouse peripheral blood platelets with RAT ANTI MOUSE CD36:Low Endotoxin(MBS605199).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Uniprot Description
CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family.
Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q11.2
Cellular Component: Golgi apparatus; extracellular space; platelet alpha granule membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; external side of plasma membrane; lipid raft
Molecular Function: low-density lipoprotein receptor activity; transforming growth factor beta binding; low-density lipoprotein binding; high-density lipoprotein binding; lipid binding
Biological Process: positive regulation of blood coagulation; positive regulation of interleukin-12 production; cGMP-mediated signaling; phagocytosis, recognition; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; negative regulation of transcription factor import into nucleus; low density lipoprotein mediated signaling; sequestering of lipid; antigen processing and presentation of peptide antigen via MHC class I; platelet degranulation; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell adhesion; positive regulation of cell-matrix adhesion; toll-like receptor 4 signaling pathway; receptor-mediated endocytosis; platelet activation; cholesterol transport; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 production; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of tumor necrosis factor production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; lipoprotein transport; toll-like receptor signaling pathway; innate immune response; lipid metabolic process; positive regulation of phagocytosis, engulfment; blood coagulation; plasma membrane long-chain fatty acid transport; nitric oxide mediated signal transduction; apoptotic cell clearance
Disease: Platelet Glycoprotein Iv Deficiency; Coronary Heart Disease, Susceptibility To, 7; Malaria, Susceptibility To
Research Articles on CD36
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Product Notes
The CD36 cd36 (Catalog #AAA605199) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The CD36, Low Endotoxin (gpIIIb, gpIV, Thrombospondin Receptor) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD36, Low Endotoxin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS), Immunofluorescence (IF). Suitable for use in Flow Cytometry, Immunofluorescence, Western Blot, Immunoprecipitation and Functional applications. Dilution: Flow Cytometry: 10ul labels 1x10e6 cells in 100ul. Researchers should empirically determine the suitability of the CD36 cd36 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD36, Low Endotoxin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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