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Mouse anti-Human CD28 Monoclonal Antibody | anti-CD28 antibody

Anti-Human CD28 (Stimulating) Antibody

Reactivity
Human
Applications
Immunoprecipitation, Flow Cytometry, Functional Assay
Purity
Protein A Purified
Synonyms
CD28; Monoclonal Antibody; Anti-Human CD28 (Stimulating) Antibody; anti-CD28 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1kappa
Specificity
Antibody ANC28.1 recognizes CD28 expressed on T cells and also on BHK cells transfected with human CD28. This antibody has been characterized as a superagonist (5)
Purity/Purification
Protein A Purified
Form/Format
Liquid; PBS, pH 7.4 with 0.02% Sodium Azide.
Concentration
1ug/ul (varies by lot)
Sequence Length
63
Applicable Applications for anti-CD28 antibody
Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes
ANC28.1 stimulates expression of IL-2 from CD28+ cells.
Immunogen
Human CD28 Ig fusion protein and HPB-MLT human tumor cells
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Related Product Information for anti-CD28 antibody
mAb name/Clone: ANC28.1/5D10Human CD28 is an important costimulatory molecule found on all CD4+ T cells and on about half of the CD8+ T cells. T cell activities attributed to CD28 include prevention of anergy, induction of cytokine gene transcription, stabilization of cytokine mRNA and activation of CD8+ cytotoxic T lymphocytes. the ligands for CD28 identified as CD80(B7-1) and CD86(B7-2), are immunglobulin superfamily monomeric transmembrane glycoproteins of 60 kd and 80 kd respectively. Anti-CD28 antibodies have recently been shown to have a strong adjuvant effect when conjugated to the immunogen (4). Antibody ANC28.1 recognizes CD28 expressed on human T cells and also on BHK cells transfected with human CD28. Monomeric and cross linked ANC28.1 will stimulate expression of IL-2 from CD28+ cells.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Official Full Name
CD28, partial
NCBI Official Synonym Full Names
CD28 antigen
NCBI Official Symbol
Cd28
NCBI Protein Information
T-cell-specific surface glycoprotein CD28

Research Articles on CD28

Similar Products

Product Notes

The CD28 (Catalog #AAA4159528) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human CD28 (Stimulating) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD28 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Flow Cytometry (FC/FACS). ANC28.1 stimulates expression of IL-2 from CD28+ cells. Researchers should empirically determine the suitability of the CD28 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD28, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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