Hamster anti-Murine CD28 Monoclonal Antibody | anti-CD28 antibody

CD28 antibody (FITC)

Cat. Num. AAA532177

• Reactivity: Murine
• Applications: Flow Cytometry, Functional Assay
• Synonyms: CD28; Monoclonal Antibody; CD28 antibody (FITC); Monoclonal CD28; Anti-CD28; CD 28; CD-28; anti-CD28 antibody

• Host: Hamster
• Reactivity: Murine
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 37.51
• Specificity: Murine
• Form/Format: Supplied as a liquid in PBS, with NaN3 added as preservative.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 63

• Applicable Applications for anti-CD28 antibody: Flow Cytometry (FC/FACS)
• Biological Significance: CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for B7.1 (CD80) and B7.2 (CD86). When activated by Toll-like receptor ligands, the B7.1 expression is upregulated in antigen presenting cells (APCs). The B7.2 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Tag/Conjugate: FITC
• Immunogen: CD28 antibody (FITC) was raised in hamster using CD28 costimulatory receptor as the immunogen.
• Preparation and Storage: Store at 4 degree C.

Related Product Information for anti-CD28 antibody

Hamster monoclonal CD28 antibody (FITC)

Product Categories/Family for anti-CD28 antibody

Immunology; Conjugated Monoclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 192485
• NCBI GeneID: 12487
• UniProt Accession #: P31041; Q6GSH7
• Molecular Weight: 25,243 Da
• NCBI Official Full Name: CD28, partial
• NCBI Official Synonym Full Names: CD28 antigen
• NCBI Official Symbol: Cd28
• NCBI Protein Information: T-cell-specific surface glycoprotein CD28
• UniProt Protein Name: T-cell-specific surface glycoprotein CD28
• Protein Family: T-cell-specific surface glycoprotein
• UniProt Gene Name: Cd28
• UniProt Entry Name: CD28_MOUSE

Uniprot Description

CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: membrane; plasma membrane; integral to membrane; immunological synapse; lipid raft; external side of plasma membrane

Molecular Function: protein homodimerization activity; protease binding; SH3/SH2 adaptor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of mitosis; T cell activation; positive regulation of interleukin-2 biosynthetic process; T cell receptor signaling pathway; negative thymic T cell selection; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of inflammatory response to antigenic stimulus; T cell costimulation; positive regulation of alpha-beta T cell proliferation; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; immune response; regulatory T cell differentiation