Mouse anti-Human CD243 Monoclonal Antibody | anti-CD243 antibody

Anti-Hu CD243 Purified Low Endotoxin

Cat. Num. AAA1801658

• Gene Names: ABCB1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Immunoprecipitation, Immunohistochemistry
• Purity: Purified by Protein-A Affinity Chromatography
• Synonyms: CD243; Monoclonal Antibody; Anti-Hu CD243 Purified Low Endotoxin; ATP binding cassette subfamily B member 1; P-Glycoprotein; CLCS; MDR1; PGY1; ABC20; GP170; ABCB1; ABC transporter; anti-CD243 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a kappa
• Clone Number: UIC2
• Specificity: The mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, or on many multidrug resistant cancer cells. This antibody preferentially recognizes CD243 in the process of transporting substrate.
• Purity/Purification: Purified by Protein-A Affinity Chromatography
• Form/Format: Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1280

• Applicable Applications for anti-CD243 antibody: Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC) Frozen/Paraffin, Functional
• Application Notes: FC/FACS: QC tested
• Immunogen: NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
• Negative Species: Mouse, Rat
• Preparation and Storage: Store at 2-8 degree C.

Related Product Information for anti-CD243 antibody

CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC)-containing efflux transporter for xenobiotic lipophilic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes).

NCBI and Uniprot Product Information

• NCBI GI #: 42741659
• NCBI GeneID: 5243
• NCBI Accession #: NP_000918.2
• NCBI GenBank Nucleotide #: NP_000918.2
• UniProt Accession #: P08183
• NCBI Official Full Name: ATP-dependent translocase ABCB1 isoform 2
• NCBI Official Synonym Full Names: ATP binding cassette subfamily B member 1
• NCBI Official Symbol: ABCB1
• NCBI Official Synonym Symbols: CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170
• NCBI Protein Information: ATP-dependent translocase ABCB1
• UniProt Protein Name: Multidrug resistance protein 1
• UniProt Gene Name: ABCB1
• UniProt Synonym Gene Names: MDR1; PGY1
• UniProt Entry Name: MDR1_HUMAN

NCBI Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]