anti-Mouse CD183/CXCR3 Monoclonal Antibody | anti-CD183/CXCR3 antibody

Anti-Mouse CD183/CXCR3 Monoclonal Antibody (AF488 Conjugated) [CXCR3-173]

Cat. Num. AAA2558793

• Gene Names: Cxcr3; Cd183; Cmkar3
• Reactivity: Mouse
• Applications: Flow Cytometry, Functional Assay
• Synonyms: CD183/CXCR3; Monoclonal Antibody; Anti-Mouse CD183/CXCR3 Monoclonal Antibody (AF488 Conjugated) [CXCR3-173]; C-X-C chemokine receptor type 3; Cxcr3; CXC-R3; CXCR-3; Interferon-inducible protein 10 receptor; IP-10 receptor; anti-CD183/CXCR3 antibody

• Host: Armenian Hamster
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: CXCR3-173
• Form/Format: PBS with 0.05% Proclin300, 1% BSA
• Concentration: 0.5 mg/mL (varies by lot)
• Sequence Length: 367

• Applicable Applications for anti-CD183/CXCR3 antibody: Flow Cytometry (FC/FACS)
• Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <= 2 ug per 10⁶ cells in 100 ul volume or 100 ul of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
• Conjugation: AF488
• Preparation and Storage: Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.

Flow Cytometry (FC/FACS)

(C57BL/6 murine splenocytes are stained with Anti-Mouse CD183/CXCR3 Monoclonal Antibody (AF488 Conjugated)(filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.)

Related Product Information for anti-CD183/CXCR3 antibody

CD183/CXCR3, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca2+ mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes or granulocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 6753458
• NCBI GeneID: 12766
• NCBI Accession #: NP_034040.1
• NCBI GenBank Nucleotide #: NP_034040.1
• UniProt Accession #: O88410
• NCBI Official Full Name: C-X-C chemokine receptor type 3
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) receptor 3
• NCBI Official Symbol: Cxcr3
• NCBI Official Synonym Symbols: Cd183; Cmkar3
• NCBI Protein Information: C-X-C chemokine receptor type 3
• UniProt Protein Name: C-X-C chemokine receptor type 3
• UniProt Gene Name: Cxcr3
• UniProt Synonym Gene Names: Cmkar3; CXC-R3; CXCR-3; IP-10 receptor

NCBI Description

This gene encodes a transmembrane protein that functions as a receptor for C-X-R chemokines. Signalling through this protein regulates a variety of biological processes, including inflammation, immunity, and would healing. This protein also plays a role in tumor growth and metastasis. [provided by RefSeq, May 2015]

Uniprot Description

Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response (). Binds to CCL21.