Flow Cytometry (FC/FACS)
(Human peripheral blood lymphocytes are stained with Anti-Human CD4 Monoclonal Antibody(FITC Conjugated) and Anti-Human CD161 Monoclonal Antibody(PE/Cyanine7 Conjugated))
Mouse anti-Human CD161 Monoclonal Antibody | anti-CD161 antibody
Anti-Human CD161 Monoclonal Antibody (PE/Cyanine7 Conjugated) [HP-3G10]
Flow Cytometry (FC/FACS)
(Human peripheral blood lymphocytes are stained with Anti-Human CD4 Monoclonal Antibody(FITC Conjugated) and Anti-Human CD161 Monoclonal Antibody(PE/Cyanine7 Conjugated))
Flow Cytometry (FC/FACS)
(Human peripheral blood lymphocytes are stained with Anti-Human CD4 Monoclonal Antibody(FITC Conjugated) and Anti-Human CD161 Monoclonal Antibody(PE/Cyanine7 Conjugated))
NCBI and Uniprot Product Information
NCBI Description
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Uniprot Description
KLRB1: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: plasma membrane; integral to membrane
Molecular Function: transmembrane receptor activity; carbohydrate binding
Biological Process: cell surface receptor linked signal transduction
Research Articles on CD161
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Product Notes
The CD161 klrb1 (Catalog #AAA2559132) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human CD161 Monoclonal Antibody (PE/Cyanine7 Conjugated) [HP-3G10] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD161 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 2 muL or 5 muL of antibody per test (million cells in 100 ul staining volume or per 100 ul of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. Researchers should empirically determine the suitability of the CD161 klrb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD161, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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