Mouse CD14 Monoclonal Antibody | anti-CD14 antibody

Mouse Anti Human CD14 FITC

Cat. Num. AAA140132

• Gene Names: NDUFA2; B8; CD14; CIB8
• Purity: Ion exchange column.
• Synonyms: CD14; Monoclonal Antibody; Mouse Anti Human CD14 FITC; CD14 Antibody; FITC; Mouse Anti-Human FITC; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD14 FITC; anti-CD14 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: hCD4
• Purity/Purification: Ion exchange column.
• Concentration: 1mg/ml in PBS (after reconstitution). (varies by lot)
• Sequence Length: 76

• Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
• Immunogen: Purified human B Cells.
• Antibody Properties: For staining, use 10 ul/1,000,000 cells.
• Available Conjugates: This antibody is also available as purified antibody and conjugated to biotin.
• Preparation and Storage: Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.

Related Product Information for anti-CD14 antibody

Introduction: CD14 (also known lipopolysaccharide (LPS) receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.

Product Categories/Family for anti-CD14 antibody

Monoclonal Antibodies; Anti-Human LYMPHOCYTES; Monoclonal Antibodies; Anti Human Lymphocyte

NCBI and Uniprot Product Information

• NCBI GI #: 297206774
• NCBI GeneID: 4695
• NCBI Accession #: NP_001171941.1
• NCBI GenBank Nucleotide #: NM_001185012.1
• Molecular Weight: 8,491 Da
• NCBI Official Full Name: NADH dehydrogenase
• NCBI Official Synonym Full Names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
• NCBI Official Symbol: NDUFA2
• NCBI Official Synonym Symbols: B8; CD14; CIB8
• NCBI Protein Information: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH-ubiquinone oxidoreductase subunit CI-B8; complex I B8 subunit
• UniProt Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
• Protein Family: Monocyte differentiation antigen
• UniProt Gene Name: NDUFA2
• UniProt Synonym Gene Names: CI-B8
• UniProt Entry Name: NDUA2_HUMAN

NCBI Description

The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Description

NDUFA2: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Protein type: Mitochondrial; EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Oxidoreductase

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: mitochondrial inner membrane; mitochondrial membrane; mitochondrial respiratory chain complex I

Molecular Function: NADH dehydrogenase (ubiquinone) activity

Biological Process: cellular metabolic process; mitochondrial electron transport, NADH to ubiquinone

Disease: Leigh Syndrome