Western Blot (WB)
(Western blot analysis of Integrin alphaM expression in human PBL whole cell lysate immunoprecipitated with Integrin alphaM (2LPM19c) and detected with Integrin alphaM (H-61).)
Mouse anti-Human, Mouse CD11b/ITAM Monoclonal Antibody | anti-CD11b/ITAM antibody
CD11b/ITAM Antibody
FC/FACS: 1ug per 1 x 106 cells
Western Blot (WB)
(Western blot analysis of Integrin alphaM expression in human PBL whole cell lysate immunoprecipitated with Integrin alphaM (2LPM19c) and detected with Integrin alphaM (H-61).)
Western Blot (WB)
(Western blot analysis of Integrin alphaM expression in human PBL whole cell lysate immunoprecipitated with Integrin alphaM (2LPM19c) and detected with Integrin alphaM (H-61).)
Immunofluorescence (IF)
(Immunofluorescence staining of methanol-fixed RAW 264.7 cells showing membrane staining.)
Immunofluorescence (IF)
(Immunofluorescence staining of methanol-fixed RAW 264.7 cells showing membrane staining.)
Flow Cytometry (FC/FACS)
(FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1.)
Flow Cytometry (FC/FACS)
(FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1.)
Flow Cytometry (FC/FACS)
(FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1.)
Flow Cytometry (FC/FACS)
(FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Description
ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cell surface; plasma membrane; integrin complex; nucleus; external side of plasma membrane
Molecular Function: heparan sulfate proteoglycan binding; heparin binding; protein binding; opsonin binding; protein heterodimerization activity; metal ion binding; glycoprotein binding
Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; extracellular matrix organization and biogenesis; microglia development; activated T cell proliferation; leukocyte migration during inflammatory response; cellular extravasation; toll-like receptor signaling pathway; innate immune response; cell adhesion; blood coagulation; toll-like receptor 4 signaling pathway; leukocyte migration
Disease: Systemic Lupus Erythematosus, Susceptibility To, 6
Research Articles on CD11b/ITAM
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Product Notes
The CD11b/ITAM itgam (Catalog #AAA9435147) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD11b/ITAM Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD11b/ITAM can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FC/FACS). IP: 1-2ug per 100-500ug of total protein (1 ml of cell lysate) FC/FACS: 1ug per 1 x 106 cells. Researchers should empirically determine the suitability of the CD11b/ITAM itgam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD11b/ITAM, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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