Dilution Information
Rabbit CD117 Monoclonal Antibody | anti-CD117 antibody
CD117 (RM359)
Reactivity
Human, Monkey, Predicted: Marmoset
Synonyms
CD117; Monoclonal Antibody; CD117 (RM359); c Kit; Kit; cKit; anti c Kit; anti c-Kit; anti CD117; anti cKit; anti-c Kit; anti-c-Kit; anti-CD117; anti-cKit; belly spot; Bs; c kit proto oncogene protein; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; kit oncogene; Mast stem cell growth factor receptor Kit; proto oncogene c Kit; proto oncogene tyrosine protein kinase Kit; SCFR; SCO1; SCO5; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr kit; Tyrosine protein kinase Kit; W; anti-CD117 antibody
Host
Rabbit
Reactivity
Human, Monkey, Predicted: Marmoset
Clonality
Monoclonal
Isotype
IgG
Clone Number
RM359
Form/Format
Paraffin, Frozen
CD117 is rabbit monoclonal antibody from supernatant diluted in Phosphate Buffered Saline, pH7.6, with protein base, and preserved with Sodium Azide preservative.
CD117 is rabbit monoclonal antibody from supernatant diluted in Phosphate Buffered Saline, pH7.6, with protein base, and preserved with Sodium Azide preservative.
Immunogen
A peptide corresponding to the C-terminus of human CD117/c-Kit.
Control
Skin, Testis, Breast, GIST, Colon, Brain, Tonsil
Localization
Cytoplasmic, Membranous, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(CD117 Antibody Immunohistochemistry on an FFPE GIST Tissue)
Immunohistochemistry (IHC)
(CD117 Antibody Immunohistochemistry on an FFPE GIST Tissue)
Related Product Information for anti-CD117 antibody
CD117 is a tyrosine-kinase receptor for stem cell factor (SCF), also known as "steel factor" or "c-kit ligand". C-kit is a polypeptide that activates bone marrow precursors of a number of blood cells, but its receptor is also present in other cells. C-kit mutations in the interstitial cells of Cajal in the digestive tract are probably the key to Gastrointestinal Stromal Tumors (GISTs).
CD117 antibody reacts with interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (Follicular and Papillary Carcinoma of the Thyroid, Adenocarcinomas from endometrium, lung, ovary, pancreas, breast; Malignant Melanoma, Endodermal Sinus Tumor, Small-cell Carcinoma) but has been particularly useful in differentiating Gastrointestinal Stromal Tumors (GIST) from Kaposi's Sarcoma and tumors of smooth-muscle origin.
CD117 antibody reacts with interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (Follicular and Papillary Carcinoma of the Thyroid, Adenocarcinomas from endometrium, lung, ovary, pancreas, breast; Malignant Melanoma, Endodermal Sinus Tumor, Small-cell Carcinoma) but has been particularly useful in differentiating Gastrointestinal Stromal Tumors (GIST) from Kaposi's Sarcoma and tumors of smooth-muscle origin.
References
1. Blood Research. "Splenic Myeloid metaplasia in warm autoimmune hemolytic anemia (wAIHA): a retrospective study".
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Product Notes
The CD117 (Catalog #AAA370523) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD117 (RM359) reacts with Human, Monkey, Predicted: Marmoset and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CD117, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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