Mouse Cathepsin D Monoclonal Antibody | anti-CTSD antibody

Mouse monoclonal Cathepsin D antibody

Cat. Num. AAA5305383

• Gene Names: CTSD; CPSD; CLN10; HEL-S-130P
• Applications: ELISA, Western Blot
• Synonyms: Cathepsin D; Monoclonal Antibody; Mouse monoclonal Cathepsin D antibody; Cathepsin D antibody; anti-CTSD antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: M78776
• Specificity: Cathepsin D antibody recognizes Cathepsin D expression in MCF7 whole cell lysate
• Form/Format: Supplied in citrate-tris-HCl buffer, pH 7.0 with 0.02% Proclin 300
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 412

• Applicable Applications for anti-CTSD antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Cathepsin D antibody was raised in Mouse using a synthetic peptide (KLH-coupled) corresponding to the residues of Cathepsin D protein as the immunogen
• Preparation and Storage: Store at -20 degree C for 1 year, store at 2-8 degree C for up to 1 month.

Immunohistochemistry (IHC)

(Immunohistochemical (1:100, 400X) analysis of Cathepsin D expression in breast cancer tissue with Cathepsin D antibody)

Product Categories/Family for anti-CTSD antibody

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 4503143
• NCBI GeneID: 1509
• NCBI Accession #: NP_001900.1
• NCBI GenBank Nucleotide #: NM_001909.4
• UniProt Accession #: P07339; Q6IB57
• Molecular Weight: 44,552 Da
• NCBI Official Full Name: cathepsin D preproprotein
• NCBI Official Synonym Full Names: cathepsin D
• NCBI Official Symbol: CTSD
• NCBI Official Synonym Symbols: CPSD; CLN10; HEL-S-130P
• NCBI Protein Information: cathepsin D
• UniProt Protein Name: Cathepsin D
• Protein Family: Cathepsin
• UniProt Gene Name: CTSD
• UniProt Synonym Gene Names: CPSD

NCBI Description

This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]

Uniprot Description

CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.

Protein type: Autophagy; EC 3.4.23.5; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular matrix; extracellular region; extracellular space; lipid raft; lysosomal lumen; lysosome

Molecular Function: cysteine-type endopeptidase activity; protein binding; serine-type endopeptidase activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagy; collagen catabolic process; protein catabolic process

Disease: Ceroid Lipofuscinosis, Neuronal, 10