Western Blot (WB)
(Western Blot: Sample: Human Serum; Primary Ab: 5ug/ml Mouse Anti-Human a2M Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody )
Mouse anti-Human Catenin Beta 1 (CTNNb1) Monoclonal Antibody | anti-CTNNb1 antibody
Anti-Catenin Beta 1 (CTNNb1) Monoclonal Antibody
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Western Blot (WB)
(Western Blot: Sample: Human Serum; Primary Ab: 5ug/ml Mouse Anti-Human a2M Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Human Serum; Primary Ab: 5ug/ml Mouse Anti-Human a2M Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody )
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Uniprot Description
CTNNB1: a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described.
Protein type: Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 3p22.1
Cellular Component: adherens junction; apical part of cell; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell-cell adherens junction; centrosome; cytoplasm; cytosol; extracellular exosome; fascia adherens; flotillin complex; focal adhesion; intercellular junction; intracellular; lamellipodium; lateral plasma membrane; membrane; microvillus membrane; nuclear euchromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription factor complex; Wnt signalosome; Z disc
Molecular Function: alpha-catenin binding; androgen receptor binding; cadherin binding; chromatin binding; DNA binding transcription factor activity; enzyme binding; estrogen receptor binding; I-SMAD binding; ion channel binding; kinase binding; nuclear hormone receptor binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase binding; protein phosphatase binding; signal transducer activity; SMAD binding; transcription coactivator activity; transcription factor binding; transcription regulatory region DNA binding
Biological Process: androgen receptor signaling pathway; anterior/posterior axis specification; beta-catenin destruction complex disassembly; beta-catenin-TCF complex assembly; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell fate specification; cell maturation; cell-matrix adhesion; cellular morphogenesis during differentiation; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chromatin-mediated maintenance of transcription; cranial skeletal system development; dorsal/ventral axis specification; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; endodermal cell fate commitment; endothelial tube morphogenesis; epithelial to mesenchymal transition; fallopian tube development; gastrulation with mouth forming second; genitalia morphogenesis; glial cell fate determination; hair cell differentiation; hair follicle morphogenesis; hindbrain development; in utero embryonic development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; male genitalia development; metanephros morphogenesis; midbrain dopaminergic neuron differentiation; negative regulation of angiogenesis; negative regulation of apoptotic signaling pathway; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of protein sumoylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nephron tubule formation; neural plate development; neuron migration; odontogenesis of dentine-containing teeth; oocyte development; osteoclast differentiation; pancreas development; positive regulation of apoptosis; positive regulation of chromatin-mediated maintenance of transcription; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-templated transcription, initiation; positive regulation of endothelial cell differentiation; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon type I production; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of muscle cell differentiation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; proteasomal ubiquitin-dependent protein catabolic process; protein localization to cell surface; proximal/distal pattern formation; regulation of angiogenesis; regulation of calcium ion import; regulation of centriole-centriole cohesion; regulation of euchromatin binding; regulation of fibroblast proliferation; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of T cell proliferation; regulation of timing of anagen; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to drug; response to estradiol; smooth muscle cell differentiation; stem cell maintenance; synapse organization; synaptic transmission; synaptic vesicle transport; T cell differentiation in thymus; thymus development; transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway; Wnt signaling pathway
Disease: Colorectal Cancer; Exudative Vitreoretinopathy 7; Hepatocellular Carcinoma; Medulloblastoma; Mental Retardation, Autosomal Dominant 19; Ovarian Cancer; Pilomatrixoma
Research Articles on CTNNb1
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Product Notes
The CTNNb1 ctnnb1 (Catalog #AAA2034674) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Catenin Beta 1 (CTNNb1) Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Catenin Beta 1 (CTNNb1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Loading Control of WB. Researchers should empirically determine the suitability of the CTNNb1 ctnnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Catenin Beta 1 (CTNNb1), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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