Dilution Information
Mouse Calponin Monoclonal Antibody | anti-CNN1 antibody
Calponin
Gene Names
CNN1; SMCC; Sm-Calp
Reactivity
Human, Canine, Feline
Synonyms
Calponin; Monoclonal Antibody; anti-CNN1 antibody
Host
Mouse
Reactivity
Human, Canine, Feline
Clonality
Monoclonal
Isotype
IgG1/K
Clone Number
CALP-A6
Form/Format
Anti-Calponin (CALP-A6) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Appendix, Uterus, Leiomyoma
Localization
Cytoplasmic
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Related Product Information for anti-CNN1 antibody
Calponin is a 34 kDa polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth-muscle contraction mechanisms and is restricted exclusively to smooth-muscle tissue. Calponin is a calcium-binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase (which is dependent upon calcium binding to calmodulin) releases the calponin's inhibition of the smooth-muscle ATPase. Calponin has been found to be useful in differentiating benign sclerosing lesions of the breast from Carcinoma. Calponin positivity has also been noted in Malignant Myoepithelioma and Pleomorphic Adenoma of Salivary Gland origin, as well as in Angiomatoid Malignant Fibrous Histiocytoma.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
33,170 Da
NCBI Official Full Name
calponin
NCBI Official Synonym Full Names
calponin 1, basic, smooth muscle
NCBI Official Symbol
CNN1
NCBI Official Synonym Symbols
SMCC; Sm-Calp
NCBI Protein Information
calponin-1; basic calponin; calponins, basic; calponin H1, smooth muscle
UniProt Protein Name
Calponin-1
Protein Family
UniProt Gene Name
CNN1
UniProt Entry Name
CNN1_HUMAN
Uniprot Description
Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity
Subunit structure: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1
Tissue specificity: Smooth muscle, and tissues containing significant amounts of smooth muscle.
Sequence similarities: Belongs to the calponin family.Contains 3 calponin-like repeats.Contains 1 CH (calponin-homology) domain.
Research Articles on CNN1
Similar Products
Product Notes
The CNN1 cnn1 (Catalog #AAA370013) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Calponin reacts with Human, Canine, Feline and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Calponin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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