BoTox-A peptide Monoclonal Antibody | anti-botA antibody
BoTox-A peptide
A. 0.05% TFA in water
B. 0.05% TFA in AcCh
Solvent Program:
Time: 0 , Flow: 1.0, %A: 10, %B: 90
Time: 30, Flow: 1.0, %A: 30, %B: 70
NCBI and Uniprot Product Information
Uniprot Description
Function: Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
Catalytic activity: Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
Cofactor: Binds 1 zinc ion per subunit.
Subunit structure: Disulfide-linked heterodimer of a light chain (L) and a heavy chain (H).
Subcellular location: Botulinum neurotoxin A light chain: Secreted. Host cytoplasm › host cytosol. Botulinum neurotoxin A heavy chain: Secreted. Host cell junction › host synapse › host presynaptic cell membrane; Multi-pass membrane protein
Potential.
Pharmaceutical use: Available under the name BOTOX (Allergan) for the treatment of strabismus and blepharospasm associated with dystonia and cervical dystonia. Also used for the treatment of hemifacial spasm and a number of other neurological disorders characterized by abnormal muscle contraction.
Miscellaneous: There are seven antigenically distinct forms of botulinum neurotoxin: Types A, B, C1, D, E, F, and G.
Sequence similarities: Belongs to the peptidase M27 family.
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Product Notes
The botA bota (Catalog #AAA352038) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Cys-Ser-Tr p-Glu-Phe- Ile-Pro-V al-Asp-Asp -Gly-Trp-G ly-COOH. It is sometimes possible for the material contained within the vial of "BoTox-A peptide, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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