Immunohistochemistry (IHC)
(Figure 1: Immunohistochemical analysis of paraffin-embedded human normal myocardium, showing cytoplasmic localization using BNP2 mouse mAb with DAB staining.)
Mouse anti-Human BNP Monoclonal Antibody | anti-BNP antibody
BNP Antibody
IHC: 1:200-1:1000
Immunohistochemistry (IHC)
(Figure 1: Immunohistochemical analysis of paraffin-embedded human normal myocardium, showing cytoplasmic localization using BNP2 mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Figure 1: Immunohistochemical analysis of paraffin-embedded human normal myocardium, showing cytoplasmic localization using BNP2 mouse mAb with DAB staining.)
Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Post-translational Modifications: The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Similarity: Belongs to the natriuretic peptide family.
NCBI and Uniprot Product Information
Predicted: 15 kDa
NCBI Description
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
Uniprot Description
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Research Articles on BNP
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Product Notes
The BNP nppb (Catalog #AAA9602512) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The BNP Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BNP can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). ELISA: 1:10000 IHC: 1:200-1:1000. Researchers should empirically determine the suitability of the BNP nppb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BNP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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