Testing Data
(Figure: Biopsy of tumor lesion from a patient with lymphoma (DLBCL) stained with MAb to APRIL (Aprily-2) . The biopsy was stained by standard immunohistochemistry. The figure shows the selective accumulation of APRIL around tumor cells.Picture courtesy of Dr. Bertrand Huard (University of Geneva).)
Mouse anti-Human APRIL Monoclonal Antibody | anti-APRIL antibody
APRIL (human) monoclonal antibody (Aprily-2)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Long term: -20°C
Avoid freeze/thaw cycles.
Ships on blue ice.
Stable for at least 1 year after receipt when stored as recommended.
Testing Data
(Figure: Biopsy of tumor lesion from a patient with lymphoma (DLBCL) stained with MAb to APRIL (Aprily-2) . The biopsy was stained by standard immunohistochemistry. The figure shows the selective accumulation of APRIL around tumor cells.Picture courtesy of Dr. Bertrand Huard (University of Geneva).)
Testing Data
(Figure: Biopsy of tumor lesion from a patient with lymphoma (DLBCL) stained with MAb to APRIL (Aprily-2) . The biopsy was stained by standard immunohistochemistry. The figure shows the selective accumulation of APRIL around tumor cells.Picture courtesy of Dr. Bertrand Huard (University of Geneva).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Uniprot Description
TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoplasm; cytosol; external side of plasma membrane; extracellular region; extracellular space; nucleoplasm
Molecular Function: cytokine activity; receptor binding; tumor necrosis factor receptor binding
Biological Process: gene expression; immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of isotype switching to IgA isotypes; regulation of mRNA stability; signal transduction; tumor necrosis factor-mediated signaling pathway
Research Articles on APRIL
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Product Notes
The APRIL tnfsf13 (Catalog #AAA565155) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 93-233. The APRIL (human) monoclonal antibody (Aprily-2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's APRIL can be used in a range of immunoassay formats including, but not limited to, IHC (PS). Immunohistochemistry (paraffin sections (1:500)) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. Researchers should empirically determine the suitability of the APRIL tnfsf13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APRIL, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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