Mouse APITD1 Monoclonal Antibody | anti-APITD1 antibody

APITD1 (Apoptosis-inducing, TAF9-like Domain 1, CENP-S, CENPS, MGC32686) (MaxLight 550)

Cat. Num. AAA6215862

• Gene Names: APITD1; MHF1; CENPS; CENP-S; FAAP16
• Applications: Western Blot
• Purity: Purified
• Synonyms: APITD1; Monoclonal Antibody; APITD1 (Apoptosis-inducing; TAF9-like Domain 1; CENP-S; CENPS; MGC32686) (MaxLight 550); Apoptosis-inducing; MGC32686; anti-APITD1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b,k
• Clone Number: 6F16
• Specificity: Recognizes APITD1.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-APITD1 antibody: FLISA, Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: APITD1 (NP_954988.1, 1aa-138aa) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: MEEEAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNSLLKYITDKSEEIAQINLERKAQKKKKSEDGSKNSRQPAEAGVVESEN
• Conjugate: MaxLight550
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-APITD1 antibody

This gene was identified in the neuroblastoma tumour suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumours, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]

Product Categories/Family for anti-APITD1 antibody

Antibodies; Fanconi Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 41327703
• NCBI GeneID: 378708
• NCBI Accession #: NP_954988.1
• NCBI GenBank Nucleotide #: NM_199294.2
• Molecular Weight: 9,074 Da
• NCBI Official Full Name: centromere protein S
• NCBI Official Synonym Full Names: apoptosis-inducing, TAF9-like domain 1
• NCBI Official Symbol: APITD1
• NCBI Official Synonym Symbols: MHF1; CENPS; CENP-S; FAAP16
• NCBI Protein Information: centromere protein S; FANCM-interacting histone fold protein 1; Fanconi anemia-associated polypeptide of 16 kDa; apoptosis-inducing TAF9-like domain-containing protein 1
• Protein Family: Centromere protein

NCBI Description

This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]