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Mouse Alkaline Phosphatase Monoclonal Antibody | anti-AP antibody

MAb to Alkaline Phosphatase

Gene Names
ALPL; HOPS; TNAP; APTNAP; TNSALP; AP-TNAP; FLJ40094; FLJ93059; MGC161443; MGC167935
Applications
Specific methodologies have not been tested using this product.
Purity
Ion exchange chromatography
Synonyms
Alkaline Phosphatase; Monoclonal Antibody; MAb to Alkaline Phosphatase; Alkaline Phosphatase (AP); anti-AP antibody
Ordering
For Research Use Only!
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
B527M
Specificity
Alkaline Phosphatase (AP)
Purity/Purification
Ion exchange chromatography
Form/Format
Purified, Liquid
Concentration
9.62 mg/ml (varies by lot)
Applicable Applications for anti-AP antibody
Specific methodologies have not been tested using this product.
Immunogen
Alkaline Phosphatase
Species Specificity
Recognizes Alkaline Phosphatase. The alkaline phosphatase (AP) maintains its enzymatic activity in the MAb-AP complex.
Affinity Constant
Not determined
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Buffer
PBS
Preservative
NaN3 (0.09% Sodium azide)
Warning
This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Preparation and Storage
Short term (up to 15 days) store at 2-8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.
Related Product Information for anti-AP antibody
MAb to Alkaline Phosphatase
Monoclonal Antibody to Alkaline Phosphatase (AP)
Product Categories/Family for anti-AP antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
249
NCBI Official Full Name
alkaline phosphatase
NCBI Official Synonym Full Names
alkaline phosphatase, liver/bone/kidney
NCBI Official Symbol
ALPL
NCBI Official Synonym Symbols
HOPS; TNAP; APTNAP; TNSALP; AP-TNAP; FLJ40094; FLJ93059; MGC161443; MGC167935
NCBI Protein Information
alkaline phosphatase, tissue-nonspecific isozyme; OTTHUMP00000002971; OTTHUMP00000002972; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase liver/bone/kidney isozyme
UniProt Protein Name
Alkaline phosphatase, tissue-nonspecific isozyme
Protein Family
UniProt Gene Name
ALPL
UniProt Entry Name
PPBT_HUMAN

NCBI Description

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq]

Uniprot Description

Function: This isozyme may play a role in skeletal mineralization.

Catalytic activity: A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor: Binds 1 magnesium ion

By similarity.Binds 2 zinc ions

Subunit structure: Homodimer.

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor Ref.10 Ref.11.

Post-translational modification: Glycosylated. Ref.9 Ref.12

Involvement in disease: Defects in ALPL are a cause of hypophosphatasia (HOPS) [

MIM:146300]. HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Ref.4 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC) [

MIM:241510].Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI) [

MIM:241500].

Sequence similarities: Belongs to the alkaline phosphatase family.

Sequence caution: The sequence BAD93051.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on AP

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Product Notes

The AP alpl (Catalog #AAA312841) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Alkaline Phosphatase can be used in a range of immunoassay formats including, but not limited to, Specific methodologies have not been tested using this product. Researchers should empirically determine the suitability of the AP alpl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Alkaline Phosphatase, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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