Mouse anti-Human AK4/Adenylate Kinase 4/AK3L1 Monoclonal Antibody | anti-AK4 antibody

Mouse anti Human AK4/Adenylate Kinase 4/AK3L1 Monoclonal Antibody

Cat. Num. AAA2543701

• Gene Names: AK4; AK3; AK 4; AK3L1; AK3L2
• Reactivity: Human
• Applications: ELISA
• Synonyms: AK4/Adenylate Kinase 4/AK3L1; Monoclonal Antibody; Mouse anti Human AK4/Adenylate Kinase 4/AK3L1 Monoclonal Antibody; anti-AK4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Sequence Length: 223

• Applicable Applications for anti-AK4 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.5-1 mug/mL. This antibody can be used at 0.5-1 mug/mL with the appropriate secondary reagents to detect Human AK4.
• Immunogen: Recombinant Human AK4/AK3L1 protein
• Buffer: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human AK4/AK3L1 (rh AK4/AK3L1; P27144-1; Ala 2-Tyr 223). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 53832003
• NCBI GeneID: 205
• NCBI GenBank Nucleotide #: NM_001005353.2
• Molecular Weight: 25,268 Da
• NCBI Official Full Name: adenylate kinase 4, mitochondrial isoform a
• NCBI Official Synonym Full Names: adenylate kinase 4
• NCBI Official Symbol: AK4
• NCBI Official Synonym Symbols: AK3; AK 4; AK3L1; AK3L2
• NCBI Protein Information: adenylate kinase 4, mitochondrial
• UniProt Protein Name: Adenylate kinase 4, mitochondrial
• UniProt Gene Name: AK4
• UniProt Synonym Gene Names: AK 4
• UniProt Entry Name: KAD4_HUMAN

NCBI Description

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Description

AK3L1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP. Belongs to the adenylate kinase family.

Protein type: EC 2.7.4.10; EC 2.7.4.6; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: adenylate kinase activity; nucleoside diphosphate kinase activity; nucleoside phosphate kinase activity; nucleoside triphosphate adenylate kinase activity

Biological Process: AMP metabolic process; ATP metabolic process; GTP metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process