Mouse anti-Human ADAM8 Ectodomain Monoclonal Antibody | anti-ADAM8 antibody

ADAM8 Ectodomain (a Disintegrin and Metalloproteinase Domain 8, MS2, CD156, CD156 MS2)

Cat. Num. AAA605246

• Gene Names: ADAM8; MS2; CD156; MGC134985
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: ADAM8 Ectodomain; Monoclonal Antibody; ADAM8 Ectodomain (a Disintegrin and Metalloproteinase Domain 8; MS2; CD156; CD156 MS2); Anti -ADAM8 Ectodomain (a Disintegrin and Metalloproteinase Domain 8; anti-ADAM8 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 9H24
• Specificity: Recognizes human ADAM8.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.

• Applicable Applications for anti-ADAM8 antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in ELISA, Western Blot, and Immunoprecipitation.; Dilution: ELISA: 1.0ug/ml; Western Blot: 1-2ug/ml; Immunoprecipitation: 25ug/ml
• Immunogen: NS0-derived, recombinant human A Disintegrin and Metalloprotease-like Domain 8 ectodomain aa158-653.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-ADAM8 antibody

Antibodies; Abs to Matrix Metalloproteinases

NCBI and Uniprot Product Information

• NCBI GI #: 109731932
• NCBI GeneID: 101
• UniProt Accession #: P78325; Q14C66
• Molecular Weight: 88,673 Da
• NCBI Official Full Name: ADAM8 protein
• NCBI Official Synonym Full Names: ADAM metallopeptidase domain 8
• NCBI Official Symbol: ADAM8
• NCBI Official Synonym Symbols: MS2; CD156; MGC134985
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 8; cell surface antigen MS2; human leukocyte differentiation antigen; a disintegrin and metalloproteinase domain 8
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 8
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: ADAM8
• UniProt Synonym Gene Names: MS2
• UniProt Entry Name: ADAM8_HUMAN

NCBI Description

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Uniprot Description

ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: specific granule; cell surface; integral to plasma membrane; cytoplasm; plasma membrane; podosome; dense core granule membrane

Molecular Function: protein binding; protein self-association; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; calcium ion binding; cell adhesion molecule binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of cell adhesion; cell morphogenesis; proteolysis; positive regulation of membrane protein ectodomain proteolysis; leukocyte migration during inflammatory response; activation of NF-kappaB transcription factor; positive regulation of T cell differentiation in the thymus; extracellular matrix disassembly; positive regulation of protein kinase B signaling cascade; cell-cell adhesion; regulation of cell-cell adhesion; positive regulation of protein secretion; positive regulation of acute inflammatory response; positive regulation of bone resorption; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; lymphocyte chemotaxis