Mouse ABCC8 Monoclonal Antibody | anti-ABCC8 antibody

ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8, ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2) (APC)

Cat. Num. AAA6169389

• Gene Names: ABCC8; HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; TNDM2; SUR1delta2
• Applications: Western Blot
• Purity: Purified
• Synonyms: ABCC8; Monoclonal Antibody; ABCC8 (ATP-Binding Cassette; Sub-Family C (CFTR/MRP); Member 8; ABC36; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; TNDM2) (APC); ATP-Binding Cassette; TNDM2; anti-ABCC8 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 30
• Specificity: Recognizes ABCC8.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-ABCC8 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: ABCC8 (NP_000343, 611aa-710aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: SEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTM
• Conjugate: APC
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Testing Data

(Detection limit for recombinant GST tagged ABCC8 is 0.03 ng/ml as a capture antibody.)

Related Product Information for anti-ABCC8 antibody

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq]

Product Categories/Family for anti-ABCC8 antibody

Antibodies; Multi Drug Resistance (MDR)

NCBI and Uniprot Product Information

• NCBI GI #: 562815400
• NCBI GeneID: 6833
• NCBI Accession #: NP_000343
• NCBI GenBank Nucleotide #: NM_001287174.1
• UniProt Accession #: Q09428; O75948; Q16583; A6NMX8; E3UYX6
• Molecular Weight: 5,468 Da
• NCBI Official Full Name: ATP-binding cassette sub-family C member 8 isoform 1
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
• NCBI Official Symbol: ABCC8
• NCBI Official Synonym Symbols: HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; TNDM2; SUR1delta2
• NCBI Protein Information: ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; sulfonylurea receptor (hyperinsulinemia); sulfonylurea receptor 1
• UniProt Protein Name: ATP-binding cassette sub-family C member 8
• Protein Family: ABC transporter C family
• UniProt Gene Name: ABCC8
• UniProt Synonym Gene Names: HRINS; SUR; SUR1

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Uniprot Description

Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.