RAGE Blocking Peptide | MOK blocking peptide

RAGE Antibody (Center) Blocking Peptide

• Gene Names: MOK; RAGE; RAGE1; STK30; RAGE-1
• Synonyms: RAGE; RAGE Antibody (Center) Blocking Peptide; MAPK/MAK/MRK overlapping kinase; MOK protein kinase; Renal tumor antigen 1; RAGE-1; MOK; RAGE1; MOK blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human RAGE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 419

• Cellular Location: Cytoplasm.
• Tissue Location: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MOK blocking peptide

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.

NCBI and Uniprot Product Information

• NCBI GI #: 41017258
• NCBI GeneID: 5891
• UniProt Accession #: Q9UQ07; Q92790; Q93067; B2R6Z4; B7Z7P6; E7ER76; E7ERR8
• Molecular Weight: 47,886 Da
• NCBI Official Full Name: MAPK/MAK/MRK overlapping kinase
• NCBI Official Synonym Full Names: MOK protein kinase
• NCBI Official Symbol: MOK
• NCBI Official Synonym Symbols: RAGE; RAGE1; STK30; RAGE-1
• NCBI Protein Information: MAPK/MAK/MRK overlapping kinase
• UniProt Protein Name: MAPK/MAK/MRK overlapping kinase
• Protein Family: MAPK/MAK/MRK overlapping kinase
• UniProt Gene Name: MOK
• UniProt Synonym Gene Names: RAGE; RAGE1; RAGE-1
• UniProt Entry Name: MOK_HUMAN

NCBI Description

This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

Uniprot Description

MOK: a CMGC protein kinase of the RCK family. Possesses a Thr-Glu-Tyr motif in the activation loop domain, as do classical MAP kinases. Associates with and is apparently stabilized by HSP90.

Protein type: EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); CMGC group; RCK family

Chromosomal Location of Human Ortholog: 14q32

Molecular Function: protein kinase activity; protein serine/threonine kinase activity

Biological Process: signal transduction