Porcine Matrix metalloproteinase 12 ELISA Kit | MMP-12 elisa kit

Porcine Matrix metalloproteinase 12 ELISA Kit

Cat. Num. AAA744837

• Gene Names: MMP12; ME; HME; MME; MMP-12
• Reactivity: Porcine
• Synonyms: Matrix metalloproteinase 12; Porcine Matrix metalloproteinase 12 ELISA Kit; MMP-12 elisa kit

• Reactivity: Porcine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Sensitivity: 1.0 pg/mL.
• Intended Uses: This MMP-12 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Porcine MMP-12. This ELISA kit for research use only, not for therapeutic applications!
• Preparation and Storage: Store all reagents at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

Product Categories/Family for MMP-12 elisa kit

Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 85567332
• NCBI GeneID: 4321
• Molecular Weight: 54,002 Da
• NCBI Official Full Name: Matrix metalloproteinase 12, preproprotein
• NCBI Official Synonym Full Names: matrix metallopeptidase 12 (macrophage elastase)
• NCBI Official Symbol: MMP12
• NCBI Official Synonym Symbols: ME; HME; MME; MMP-12
• NCBI Protein Information: macrophage metalloelastase; matrix metalloproteinase 12 (macrophage elastase)
• UniProt Protein Name: Macrophage metalloelastase
• UniProt Gene Name: MMP12
• UniProt Synonym Gene Names: HME; MME; ME; hME; MMP-12
• UniProt Entry Name: MMP12_HUMAN

NCBI Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Uniprot Description

MMP12: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. Belongs to the peptidase M10A family.

Protein type: EC 3.4.24.65; Secreted, signal peptide; Secreted; Protease

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; endopeptidase activity; calcium ion binding

Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of epithelial cell proliferation involved in wound healing; proteolysis; wound healing, spreading of epidermal cells