Mouse MAP kinase interacting serine/threonine kinase 2 ELISA Kit | MKNK2 elisa kit
Mouse MAP kinase-interacting serine/threonine-protein kinase 2, MKNK2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]
Uniprot Description
Mnk2: a ubiquituous CAM kinase of the MAPKKAPK family. Regulates translation by phosphorylating S209 of eIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. The phosphorylation of eIF4E S209 by the MNK1/2 kinases is required for eIF4E's oncogenic action. Phosphorylates Spry2 on S112 and S121, leading to the ubiquitination and degradation of Spry2. Five splice-variant isoforms have been described.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CAMK; Translation; CAMK group; MAPKAPK family; MNK subfamily
Cellular Component: nucleoplasm; cytoplasm; nucleolus; intracellular; nucleus
Molecular Function: calmodulin binding; transferase activity; protein serine/threonine kinase activity; protein binding; calcium-dependent protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: regulation of translation; peptidyl-serine phosphorylation; apoptosis; protein amino acid autophosphorylation; hemopoiesis; protein amino acid phosphorylation; phosphorylation
Research Articles on MKNK2
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Product Notes
The Mouse MKNK2 mknk2 (Catalog #AAA9342905) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342905 ELISA Kit recognizes Mouse MKNK2. It is sometimes possible for the material contained within the vial of "MAP kinase interacting serine/threonine kinase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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