Mediator of RNA polymerase II transcription subunit 12 (MED12) Recombinant Protein | MED12 recombinant protein

Recombinant Human Mediator of RNA polymerase II transcription subunit 12 (MED12) , partial

Cat. Num. AAA1448623

• Gene Names: MED12; OKS; FGS1; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Mediator of RNA polymerase II transcription subunit 12 (MED12); Recombinant Human Mediator of RNA polymerase II transcription subunit 12 (MED12); partial; MED12 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1616-2051. Partial, provide the Interaction with CTNNB1 and GLI3 Region
• Sequence: LAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQ
• Sequence Length: 2051

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for MED12 recombinant protein

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains This protein, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

NCBI and Uniprot Product Information

• NCBI GI #: 110347429
• NCBI GeneID: 9968
• NCBI Accession #: NP_005111.2
• NCBI GenBank Nucleotide #: NM_005120.2
• UniProt Accession #: Q93074; O15410; O75557; Q9UHV6; Q9UND7
• Molecular Weight: 242,953 Da
• NCBI Official Full Name: mediator of RNA polymerase II transcription subunit 12
• NCBI Official Synonym Full Names: mediator complex subunit 12
• NCBI Official Symbol: MED12
• NCBI Official Synonym Symbols: OKS; FGS1; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230
• NCBI Protein Information: mediator of RNA polymerase II transcription subunit 12
• UniProt Protein Name: Mediator of RNA polymerase II transcription subunit 12
• Protein Family: Mediator of RNA polymerase II transcription
• UniProt Gene Name: MED12
• UniProt Synonym Gene Names: ARC240; CAGH45; HOPA; KIAA0192; TNRC11; TRAP230; ARC240; Trap230

NCBI Description

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

Uniprot Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.