Structure
MDL 105519, Inhibitor | MDL105519, inhibitor
MDL 105519
Purity
98.00%
Synonyms
MDL 105519; MDL105519; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 17mg/mL (45.19mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C18H11Cl2NO4
SMILES
O=C(O)C(N1)=C(/C=C(C2=CC=CC=C2)/C(O)=O)C3=C1C=C(Cl)C=C3Cl
CAS Number
161230-88-2
Target & IC50
Others
In Vitro
MDL 105519 is annMDA receptor antagonist in vivo. MDL 105519 (intravenously administration) prevents harmaline-stimulated increases in cerebellar cyclic GMP content, providing biochemical evidence of nMDA receptor antagonism in vivo. Anxiolytic activity is observed in the rat separation-induced vocalization model, but muscle-relaxant activity is apparent at lower doses. This antagonism is associated with anticonvulsant activity in genetically based, chemically induced, and electrically mediated seizure models. Higher doses impair rotorod performance but are without effect on mesolimbic dopamine turnover or prepulse inhibition of the startle reflex.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for MDL105519, inhibitor
MDL 105519 is an effective antagonist of glycine binding to thenMDA receptor.
References
Baron BM, et al. Pharmacological characterization of MDL 105,519, annMDA receptor glycine site antagonist. Eur J Pharmacol. 1997 Apr 4;323(2-3):181-92.
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Product Notes
The MDL105519 (Catalog #AAA5755175) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MDL 105519, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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