Melanocortin receptor 4 (Mc4r) Recombinant Protein | Mc4r recombinant protein
Recombinant Mouse Melanocortin receptor 4 (Mc4r)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]
Uniprot Description
MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Cellular Component: integral to membrane; membrane; nucleus; plasma membrane
Molecular Function: G-protein coupled receptor activity; melanocortin receptor activity; melanocyte stimulating hormone receptor activity; neuropeptide binding; peptide hormone binding; protein binding; signal transducer activity; ubiquitin protein ligase binding
Biological Process: diet induced thermogenesis; energy reserve metabolic process; feeding behavior; G-protein coupled receptor protein signaling pathway; insulin secretion; positive regulation of bone resorption; positive regulation of cAMP biosynthetic process; regulation of metabolic process; response to insulin stimulus; signal transduction
Research Articles on Mc4r
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Product Notes
The Mc4r mc4r (Catalog #AAA7019951) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-332aa; Full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Mc4r mc4r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MNSTHHHGMY TSLHLWNRSS YGLHGNASES LGKGHPDGGC YEQLFVSPEV FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT IFYALQYHNI MTVRRVGIII SCIWAACTVS GVLFIIYSDS SAVIICLISM FFTMLVLMAS LYVHMFLMAR LHIKRIAVLP GTGTIRQGTN MKGAITLTIL IGVFVVCWAP FFLHLLFYIS CPQNPYCVCF MSHFNLYLIL IMCNAVIDPL IYALRSQELR KTFKEIICFY PLGGICELSS RY. It is sometimes possible for the material contained within the vial of "Melanocortin receptor 4 (Mc4r), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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