Melanocortin 4 Receptor Assay System | MC4R assay system
Melanocortin 4 Receptor (MC4R) ACTOne Stable Cell Line
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
Uniprot Description
MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 18q22
Cellular Component: plasma membrane; integral to membrane; nucleus
Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; peptide hormone binding; ubiquitin protein ligase binding; melanocyte stimulating hormone receptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; response to insulin stimulus
Disease: Obesity
Research Articles on MC4R
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Product Notes
The MC4R mc4r (Catalog #AAA433624) is an Assay System and is intended for research purposes only. The product is available for immediate purchase. cAMP dependent human MC4R cell-based assay; cell-based high-throughput screening of human MC4R inhibitors. Researchers should empirically determine the suitability of the MC4R mc4r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Melanocortin 4 Receptor, Assay System" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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