Membrane-bound transcription factor site-1 protease (Mbtps1) Recombinant Protein | Mbtps1 recombinant protein

Recombinant Mouse Membrane-bound transcription factor site-1 protease (Mbtps1) , partial

Cat. Num. AAA1428165

• Gene Names: Mbtps1; S1P; Ski1; SKI-1; AV003995; mKIAA0091; 0610038M03Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Membrane-bound transcription factor site-1 protease (Mbtps1); Recombinant Mouse Membrane-bound transcription factor site-1 protease (Mbtps1); partial; Mbtps1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,052

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Mbtps1 recombinant protein

The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein.

NCBI and Uniprot Product Information

• NCBI GI #: 268836232
• NCBI GeneID: 56453
• NCBI Accession #: NP_001161382.1
• NCBI GenBank Nucleotide #: NM_001167910.1
• UniProt Accession #: Q9WTZ2; Q6PG67
• Molecular Weight: 117,457 Da
• NCBI Official Full Name: membrane-bound transcription factor site-1 protease
• NCBI Official Synonym Full Names: membrane-bound transcription factor peptidase, site 1
• NCBI Official Symbol: Mbtps1
• NCBI Official Synonym Symbols: S1P; Ski1; SKI-1; AV003995; mKIAA0091; 0610038M03Rik
• NCBI Protein Information: membrane-bound transcription factor site-1 protease
• UniProt Protein Name: Membrane-bound transcription factor site-1 protease
• Protein Family: Membrane-bound transcription factor site-1 protease
• UniProt Gene Name: Mbtps1
• UniProt Synonym Gene Names: S1p; Ski1; SKI-1

Uniprot Description

Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes ().