Human methionine adenosyltransferase I, alpha ELISA Kit | MAT1A elisa kit
Human S-adenosylmethionine synthase isoform type-1, MAT1A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
Uniprot Description
MAT1A: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD); also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. Belongs to the AdoMet synthase family.
Protein type: Amino Acid Metabolism - cysteine and methionine; Other Amino Acids Metabolism - selenoamino acid; Transferase; EC 2.5.1.6
Chromosomal Location of Human Ortholog: 10q22
Cellular Component: cytosol
Molecular Function: methionine adenosyltransferase activity; metal ion binding; ATP binding
Biological Process: methylation; amino acid metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process
Disease: Methionine Adenosyltransferase Deficiency
Research Articles on MAT1A
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Product Notes
The Human MAT1A mat1a (Catalog #AAA9325210) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325210 ELISA Kit recognizes Human MAT1A. It is sometimes possible for the material contained within the vial of "methionine adenosyltransferase I, alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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