TEB4 / MARCH-VI Blocking Peptide | MARCH6 blocking peptide
TEB4 / MARCH-VI Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Description
MARCH6: E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
Protein type: EC 6.3.2.19; Ligase; Membrane protein, multi-pass; EC 6.3.2.-; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 5p15.2
Cellular Component: integral to endoplasmic reticulum membrane; integral to membrane; membrane
Molecular Function: enzyme binding; ligase activity; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: proteasomal protein catabolic process
Research Articles on MARCH6
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Product Notes
The MARCH6 march6 (Catalog #AAA426474) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The TEB4 / MARCH-VI Immunizing Peptide reacts with Human, Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-QGRRVIFQ KVKE. It is sometimes possible for the material contained within the vial of "TEB4 / MARCH-VI, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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