JIP3 / Syd2 / JSAP1 Blocking Peptide | MAPK8IP3 blocking peptide

JIP3 / Syd2 / JSAP1 Immunizing Peptide

Cat. Num. AAA425241

• Gene Names: MAPK8IP3; syd; JIP3; SYD2; JIP-3; JSAP1
• Reactivity: Human, Mouse, Rat, Cow
• Synonyms: JIP3 / Syd2 / JSAP1; JIP3 / Syd2 / JSAP1 Immunizing Peptide; MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3; JIP3; SYD2; JSAP1; FLJ00027; KIAA1066; JNK-interacting protein 3; JNK/SAPK-associated protein-1; similar to sperm specific protein; homolog of Drosophila Sunday driver 2; JNK/stress-activ; MAPK8IP3 blocking peptide

• Reactivity: Human, Mouse, Rat, Cow
• Form/Format: 100ug of dried peptide
• Sequence: MEIQMDEGGGVV-C
• Sequence Length: 1336

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 94557297
• NCBI GeneID: 23162
• NCBI Accession #: NP_055948.2; NP_001035529.1
• NCBI GenBank Nucleotide #: NM_015133.4
• Molecular Weight: 29,052 Da
• NCBI Official Full Name: C-Jun-amino-terminal kinase-interacting protein 3 isoform 1
• NCBI Official Synonym Full Names: mitogen-activated protein kinase 8 interacting protein 3
• NCBI Official Symbol: MAPK8IP3
• NCBI Official Synonym Symbols: syd; JIP3; SYD2; JIP-3; JSAP1
• NCBI Protein Information: C-Jun-amino-terminal kinase-interacting protein 3
• UniProt Protein Name: C-Jun-amino-terminal kinase-interacting protein 3
• Protein Family: C-Jun-amino-terminal kinase-interacting protein
• UniProt Gene Name: MAPK8IP3
• UniProt Synonym Gene Names: JIP3; KIAA1066; JIP-3; JNK-interacting protein 3
• UniProt Entry Name: JIP3_HUMAN

NCBI Description

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

JIP3: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: axolemma; cytoplasm; dendrite; Golgi membrane; smooth endoplasmic reticulum

Molecular Function: JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; receptor signaling complex scaffold activity

Biological Process: activation of JNK activity; alveolus development; axon guidance; forebrain development; in utero embryonic development; post-embryonic development; protein localization; regulation of gene expression; regulation of JNK cascade; respiratory gaseous exchange; vesicle-mediated transport