SDS-PAGE
ERK2 / MAPK1 / MAPK2 recombinant protein
Recombinant Mouse ERK2 / MAPK1 / MAPK2 Protein
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
Uniprot Description
ERK2: a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates.
Protein type: CMGC group; EC 2.7.11.24; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16 A3|16 10.53 cM
Cellular Component: axon; caveola; cytoplasm; cytoskeleton; cytosol; dendrite cytoplasm; early endosome; focal adhesion; Golgi apparatus; late endosome; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; perikaryon; protein complex; pseudopodium
Molecular Function: ATP binding; kinase activity; MAP kinase activity; mitogen-activated protein kinase kinase kinase binding; phosphatase binding; phosphotyrosine binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; RNA polymerase subunit kinase activity; transcription factor binding
Biological Process: B cell receptor signaling pathway; Bergmann glial cell differentiation; cytosine metabolic process; heart development; lipopolysaccharide-mediated signaling pathway; mammary gland epithelial cell proliferation; MAPKKK cascade; negative regulation of cell differentiation; neural crest cell development; nuclear translocation of MAPK; organ morphogenesis; outer ear morphogenesis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of translation; protein amino acid phosphorylation; regulation of cytoskeleton organization and biogenesis; regulation of ossification; regulation of stress-activated MAPK cascade; response to DNA damage stimulus; response to estrogen stimulus; response to exogenous dsRNA; response to lipopolysaccharide; response to toxin; sensory perception of pain; signal transduction; T cell receptor signaling pathway; thymus development; thyroid gland development
Research Articles on ERK2 / MAPK1 / MAPK2
Similar Products
Product Notes
The ERK2 / MAPK1 / MAPK2 mapk1 (Catalog #AAA2546981) is a Recombinant Protein produced from Baculovirus-Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse MAPK1 consists of 360 amino acids and predicts a molecular mass of 41.4 KDa. It migrates as an approximately 37 KDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the ERK2 / MAPK1 / MAPK2 mapk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERK2 / MAPK1 / MAPK2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
